DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RasGAP1 and rasa2

DIOPT Version :9

Sequence 1:	NP_001261664.1	Gene:	RasGAP1 / 39158	FlyBaseID:	FBgn0004390	Length:	1181	Species:	Drosophila melanogaster
Sequence 2:	NP_001090666.1	Gene:	rasa2 / 100036638	XenbaseID:	XB-GENE-480785	Length:	834	Species:	Xenopus tropicalis

Alignment Length:	980	Identity:	321/980 - (32%)
Similarity:	500/980 - (51%)	Gaps:	178/980 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VRIEEQLKVKIGEAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQ 103
            ||:.:.|:.||.|||.|...:..|.      .||.:||:.||||||.||..:|::||||:||:..
Frog    21 VRLLQSLRGKICEAKQLLPYSGPNK------MRDCFCTVNLDQEEIFRTKVVEKSLTPFYGEDFY 79

  Fly   104 FKIPRRFRYLTIYLWDRD-MKQDKPIGKIAIKREELHMYNHKDHWFSLRPVDQDSEVQGMVNVEV 167
            |:|||.|..|:.|::|:: :::|..|||::||:|:|...|.|:.||.|:|:|.:|||||.:::|:
Frog    80 FEIPRTFHNLSFYIYDKNVLQRDLRIGKVSIKKEDLCSSNGKETWFPLQPIDPNSEVQGKLHLEL 144

  Fly   168 AFTEAQQTQSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAA 232
                     .|:|.|                              :|..::|:
Frog   145 ---------KLNELI------------------------------TENGSVQQ------------ 158

  Fly   233 MTLKTRAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKKQGT 297
                     |..|:    .:.:..|::|..|
Frog   159 ---------LMVHI----LECEGLPLVNGQS---------------------------------- 176

  Fly   298 CDPFV-VCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLESS 361
            |||:. |.....|...|  :|||.:|||.:|:|:|..||::       :.:::.:.||...:|..
Frog   177 CDPYASVSVVGPSRNEQ--KRTKVKKKTSNPQFNEKFYFEV-------TRSSSYTKKSHFQVEEE 232

  Fly   362 ANKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSAWYYLQPRSM 426
                       ..:.:|:.|.:|:  :|.:...|||||:|:.:  |..:...:..|||.|||:.
Frog   233 -----------DIEKLEVRVDLWN--NGNLGQDVFLGEIRISV--KVLRNDSSHRAWYLLQPKD- 281

  Fly   427 THSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPIT 491
                             .|::.|....:|.|||::.||.|||.....|..|.:|:|:|.:.|||:
Frog   282 -----------------NGSKTSKYDDLGFLRLSICYTEDHVLSSDCYSSLRSLILKSPEVRPIS 329

  Fly   492 VSAVSILGELVSGKTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSKMMDE 556
            .|...||||:...|.:...|||||..|.:::.|.:..:|..:::...:..||||||:|.::.:||
Frog   330 ASPAFILGEVCRDKYDAVLPLVRLLLHHQKLVPFVAEIAQLDLNDTQEANTIFRGNSLATRCLDE 394

  Fly   557 AMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYVERVFEAITKSADR 621
            .|::.|.|||..||:.||.:|....|||||||:::|:...||.:..||:.||::||..|.||:..
Frog   395 TMKIVGKHYLKVTLKNVLDEICDSPKPCEIDPNRLKEGDNVDNHKENLRYYVDKVFFCIVKSSMS 459

  Fly   622 CPKVLCQIFHDLRECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTL 686
            ||.|:|.||..||..|.:|||.:..|:||.||.|:||||||.|::.|..|.|.....||||||.|
Frog   460 CPTVMCDIFSTLRHMAVKHFPKDPHVQYSAVSSFVFLRFFAVAVVSPHSFQLRPHHPDAQTSRIL 524

  Fly   687 TLISKTIQSLGNLVS-SRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFLEVISTPSHASSSVHPA 750
            ||||||||:||::.| ::|...:.||:|..:.:|.|..|.:...||.|||.||    ::.:..|:
Frog   525 TLISKTIQTLGSVSSLTKSKPSSFKEQFMCDFFKMFEEETYTKVVKKFLEEIS----STETKEPS 585

  Fly   751 AAAATPLEPVLLKEGLMTKYPTSRKRFGRQ-FKQRHFRLTTHSLSYAKSKGKQPICDIPLQEIAS 814
            ..:    |.::||||.|.|....|.|.|:: ||:|.|.||:|.|:|.|.|.|:|:..||::.|.:
Frog   586 GVS----ESLILKEGEMHKRALGRTRIGKKNFKKRWFSLTSHELTYHKQKDKEPVFSIPIKNILA 646

  Fly   815 VEQLKDKSFKMQNCFKIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFVSGFY 879
            ||:|.:.:|...|.|:::||::.|.:|..||:|..||.::|..:...|..|:..:|||.|:.|.:
Frog   647 VERLDESAFSKNNMFQVIHNEKPLYIQANNCIEANEWIEILSGLSRRNQKRLSKYHPSVFLGGSW 711

  Fly   880 SCCGRSDENSPGCKKVLDKTMDYFQMDLVTALDPALDLQRIHTLIMSNMSVL---ESLLDPLTYH 941
            .||..:::.:.||   ...|:| ...|:...:|...:.:|||.|...||..|   |.....:..:
Frog   712 LCCKAANDGTEGC---CPCTVD-VPADVALDIDGDRECERIHRLFSVNMQKLLKMEEACGTIAVY 772

  Fly   942 QSLSQTQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLREKAYAIDRDHRDYKQGITRQLKYGS 1006
            |. .|.:|..:|..:..:....|    ...:.|...|.|:|.       |..:|:|.| ..||||
Frog   773 QG-PQKEHSDYNFTIEDSVTTFK----VLQQIKAITENLKEL-------HDKHKKGST-SAKYGS 824

  Fly  1007 RQAPI 1011
            ::.||
Frog   825 QENPI 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	56/125 (45%)
		C2B_RasA3	280..462	CDD:175977	43/182 (24%)
		RasGAP	449..797	CDD:214617	150/349 (43%)
		RasGAP_GAP1_like	473..740	CDD:213330	120/267 (45%)
		PH	761..859	CDD:278594	41/98 (42%)
		PH_GAP1-like	763..867	CDD:269950	42/104 (40%)
		BTK	862..897	CDD:128417	11/34 (32%)
rasa2	NP_001090666.1	C2A_RasA2_RasA3	26..146	CDD:176046	56/134 (42%)
		C2B_RasA3	158..300	CDD:175977	48/242 (20%)
		RasGAP_RASA2	309..580	CDD:213342	120/274 (44%)
		PH_GAP1m_mammal-like	577..709	CDD:241521	50/139 (36%)
		BTK	694..728	CDD:382978	11/36 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	119	1.000	Domainoid score	I5733
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	622	1.000	Inparanoid score	I862
OMA	1	1.010	-	-		QHG49607
OrthoDB	1	1.010	-	-		D145372at2759
OrthoFinder	1	1.000	-	-		FOG0000825
OrthoInspector	1	1.000	-	-		otm48987
Panther	1	1.100	-	-	O	PTHR10194
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R472
SonicParanoid	1	1.000	-	-		X2711
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110