DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RasGAP1 and syngap1a

DIOPT Version :9

Sequence 1:	NP_001261664.1	Gene:	RasGAP1 / 39158	FlyBaseID:	FBgn0004390	Length:	1181	Species:	Drosophila melanogaster
Sequence 2:	XP_005159373.1	Gene:	syngap1a / 100034485	ZFINID:	ZDB-GENE-060503-370	Length:	1313	Species:	Danio rerio

Alignment Length:	1263	Identity:	257/1263 - (20%)
Similarity:	404/1263 - (31%)	Gaps:	385/1263 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 QEEICRTPTIERTLTPFFGEEHQFKIPRRFRYLTI------YLWDRDMKQDKPIGKIAIKREELH 139
            |:..|.:| ..|..||..|..|.  .|...|.|.:      ||.|               :||:|
Zfish     7 QDGRCVSP-CSRPHTPLNGHAHD--SPGWSRQLRVRDGDQFYLLD---------------QEEVH 53

  Fly   140 MYNHKDHWFSLRPVDQDSEVQGMVNVEVAFTEAQQTQSLSEGIDLGQHTLRHHQNLPHHS---HQ 201
            .....||    |||....::              ..:::|...|...|....|......|   .:
Zfish    54 PLLMNDH----RPVSHRHKL--------------LRRTVSVPADSRPHPESEHARARRKSFATSR 100

  Fly   202 QR-------AHLNDYKENSELSNIQRASAAAASSSSAAMTLKTRAAGLFGHVHHPPSQT------ 253
            ||       |....:::.|.||...:.|...|.|..     |....|.|.|:..|..::
Zfish   101 QRSMETPPTAPTQPFRQPSFLSRRLKGSIKRAKSQP-----KLDRTGSFRHMILPRFRSADQERT 160

  Fly   254 ---QHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPA--------------CVDLAKKQGT---- 297
               |.|    ..|.|.:.|.:..|....:.:|:...|              |.::....||
Zfish   161 RLMQSF----KESHSHESLLSPSSAAEALDLTLDEDAIIKPVHSSILGQEYCFEVTTASGTKCFA 221

  Fly   298 CDPFVVCTAHYSNKHQVTRRTKQRKKTVD--------------PEFDEAMYFDLHIDADAGSTNT 348
            |...........|..:..:..|...:.||              |:  :..|.:|.:| |.....|
Zfish   222 CRSAAERDKWIENLQRAVKPNKDNSRRVDNVLKLWIIEARDLPPK--KRYYCELCLD-DMLYART 283

  Fly   349 T----------GSNKSAGSLESSANKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLP 403
            |          |.:....:|.:..:....:|..             :|.........:||.|.:|
Zfish   284 TSKPRTDTVFWGEHFEFNNLPAIRSLRLHLYKE-------------NDKKRRKEKSTYLGLVSIP 335

  Fly   404 MLNKQEQQAVNPSAWY-YLQPRSMTH----SSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNY 463
            :.:...:|.|  ..|| .:||..:..    ..:.:||                    ||||...:
Zfish   336 IPSVTGRQFV--EQWYPLIQPSVLAKGGGGGGKIINA--------------------SLRLKSRF 378

  Fly   464 TADHVFPLATYDDLMNLLLESVDQRPITVSAVSILGELVSGKT--EVAQPLVRLFTHTERIAPII 526
            .:.::.|:..|.:    ..|.|.....|:..|  |..|:|.|:  |||..||.:...|.:....:
Zfish   379 QSMNILPMELYKE----FAEYVTNNYRTLCGV--LEPLLSAKSKEEVACALVHILQSTGKAKDFL 437

  Fly   527 KALADHEISHLTD-PTTIFRGNTLVSKMMDEAMRLSGLHYLHQTL--RPVLSQIVAEKKPCEID- 587
            ..:|..|:....| ...|||.|||.:|.::|.::|....||..|:  ...:..:...::.||:|
Zfish   438 SDMAMCEVDRFMDREHLIFRENTLATKAIEEFLKLIAHRYLKDTIGEGEFIRALYESEENCEVDP 502

  Fly   588 ----PSKIKDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDLR-ECAGEHFPSNREV 647
                ||.:.|..|      ||:...|.....|..|....|:.|.::|...| .||..   ...::
Zfish   503 MRTPPSVLADHQA------NLRMCCELALCKIINSHCVFPRELKEVFASWRVRCAER---GREDI 558

  Fly   648 RYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQT---- 708
            ...::|..:||||..|||:.|.||:||.|....:||||||||:|.:|||.:. |..|.::.
Zfish   559 ADRLISSSLFLRFLCPAIMSPSLFNLTQEYPSERTSRTLTLIAKVVQSLASF-SKFSGKEDYLGF 622

  Fly   709 ----------CKEEFTVELYKKFCT------EQHVD-----AVKHFL--EVISTPSHASSSVHPA 750
                      ..::|..|:....|.      |.::|     ::.|.|  ||::..|      ..|
Zfish   623 MNEFLEMEWGSMQQFLYEISNLECVSNAGAFEGYIDLGRELSILHSLLWEVMAQLS------KDA 681

  Fly   751 AAAATPLEPVLLKEGLMTKYPTSRKRFGRQFKQRHFRLTTHSLSYAKSKGKQPICDIPLQEIASV 815
            .....||..:|....:..:.|...::...|..:||  |:..:.|...:...|.:....|.....:
Zfish   682 ILKLGPLPRLLNDISVALRNPQLHRQASHQPPERH--LSRPAFSRLATNDFQSLMMRDLNSSIDI 744

  Fly   816 EQLKDKSFKMQNCFKIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFVSGFY- 879
            .:|...:..:.....:.|...:       ...||:                    |......||
Zfish   745 SRLPSPTAGLSGSGVLSHPGMA-------AFSERD--------------------PRGNKDVFYV 782

  Fly   880 -----------SCCGRSDENSPGCKKVLDKTMDYFQMDLV-TALDPALDLQRIHTLIMSNMSVLE 932
                       .|...||...|. .|||........|||. :.::...:|..::.|:.|:...|.
Zfish   783 TRPPLARSSPAYCTSSSDITEPD-PKVLSVNKSVSMMDLQDSRINSVSNLHSVNDLLNSSQGSLA 846

  Fly   933 SLLDPL-------------------------TYHQSLSQTQHQQ----------HNPLVPLATD- 961
            . ..||                         ....||||.|.|.          .|||..||:|
Zfish   847 G-FGPLGGAPLRAGGRVSAGSGGSSMSGGLRLTTDSLSQQQQQAAAAMHVPLSFQNPLFHLASDG 910

  Fly   962 LQKHSPQ----------------------------AFAEFKRTIEKLREKAYAIDRDHRDYKQGI 998
            .|.|:|.                            |.:.|.|:     |...|:...:...:..|
Zfish   911 PQYHTPPHGPTAVPPPLLLAPEPENGHVGFGVPTFAHSGFSRS-----EDLSALRTQNSLVQPNI 970

  Fly   999 TRQLKYGSRQAPIGDDNYWHMMRAAGQLNQQHHQQQQHQQQQQQQQQQQLQQFQPQPVLPQMQNV 1063
            .....|        .|::           .:|:|....::|...|.|:.|||.....:.||....
Zfish   971 VHSHSY--------SDDF-----------TRHNQADYARRQLSLQVQENLQQQVLMGMTPQTATG 1016

  Fly  1064 RAYPYQPATSNMNAYCLHNMQYQQQRLPFHQQQQQHHQQLQQQQSQFQPLRSHQLQRHNNNLNNN 1128
            ...|...||....               .|..:|........|:::.||  :|||
Zfish  1017 TGTPASLATPPTT---------------IHPVRQASMAPPPPQRAKPQP--AHQL---------- 1054

  Fly  1129 NCGNGSSSSPSSTTSSVVAAPPSTTSSS 1156
                       |.:|:|.:.||.|...|
Zfish  1055 -----------SVSSAVNSTPPKTRPQS 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	22/93 (24%)
		C2B_RasA3	280..462	CDD:175977	37/228 (16%)
		RasGAP	449..797	CDD:214617	101/385 (26%)
		RasGAP_GAP1_like	473..740	CDD:213330	85/304 (28%)
		PH	761..859	CDD:278594	13/97 (13%)
		PH_GAP1-like	763..867	CDD:269950	12/103 (12%)
		BTK	862..897	CDD:128417	9/46 (20%)
syngap1a	XP_005159373.1	PH-like	108..299	CDD:302622	36/202 (18%)
		C2_SynGAP_like	241..386	CDD:175980	30/182 (16%)
		RasGAP	366..694	CDD:214617	97/369 (26%)
		RasGAP_DAB2IP	377..702	CDD:213338	91/346 (26%)
		DUF3498	692..1289	CDD:288827	83/473 (18%)
		GrpE	1173..>1288	CDD:295646
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577573
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840