Protein Alignment Cdk8 and CDK11B

DIOPT Version :10

• Sequence 1: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: XP_011540792.1
• Gene: CDK11B / 984
• HGNCID: 1729
• Length: 804
• Species: Homo sapiens
• Alignment Length: 333
• Identity: 117/333 - (35%)
• Similarity: 189/333 - (56%)
• Gaps: 47/333 - (14%)

  Fly    23 EGC----------KVGRGTYGHVYKAKWKETSDGKEYALKQI----DGTGLSMSACREIALLREL 73
            :||          ::..||||.||:||.|:|.:  ..|||::    :..|..:::.|||..:.:.
Human   439 QGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDE--IVALKRLKMEKEKEGFPITSLREINTILKA 501

  Fly    74 KHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMVKSLLYQILDG 138
            :|.|::|:..:.:..|..|::::::|.||||       ::...|.||..:| |.||:|:.|:|.|
Human   502 QHPNIVTVREIVVGSNMDKIYIVMNYVEHDL-------KSLMETMKQPFLP-GEVKTLMIQLLRG 558

  Fly   139 IHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPE 203
            :.:||.||:||||||.:|:|:    :..|.:|:.|.|.||.:.:|||...   |||||.||||||
Human   559 VKHLHDNWILHRDLKTSNLLL----SHAGILKVGDFGLAREYGSPLKAYT---PVVVTLWYRAPE 616

  Fly   204 LLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWE 268
            |||||:.|:.|:|:|::||||.||||.:|:|..:.|         .||::::|..:|.|.:|.|.
Human   617 LLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSE---------IDQINKVFKDLGTPSEKIWP 672

  Fly   269 DIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDQ 333
            ...::|.       .|:.|:|........:|.......:.|.|:.|.|...|.:||::|..::.:
Human   673 GYSELPA-------VKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHE 730

  Fly   334 YFQEEPQP 341
            ||:|.|.|
Human   731 YFRETPLP 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	112/325 (34%)
CDK11B	XP_011540792.1	STKc_CDC2L1	441..732	CDD:173741	111/323 (34%)