Protein Alignment Cdk8 and CDK1

DIOPT Version :10

• Sequence 1: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_001777.1
• Gene: CDK1 / 983
• HGNCID: 1722
• Length: 297
• Species: Homo sapiens
• Alignment Length: 337
• Identity: 124/337 - (36%)
• Similarity: 187/337 - (55%)
• Gaps: 65/337 - (19%)

  Fly    14 TKVEDLFNYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQI----DGTGLSMSACREIALLRELK 74
            ||:|        |:|.||||.|||.:.|.|  |:..|:|:|    :..|:..:|.|||:||:||:
Human     5 TKIE--------KIGEGTYGVVYKGRHKTT--GQVVAMKKIRLESEEEGVPSTAIREISLLKELR 59

  Fly    75 HQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQV-VVPRG------MVKSLL 132
            |.|:::|..|.:  .|.:::|:.::...||             ||.: .:|.|      :|||.|
Human    60 HPNIVSLQDVLM--QDSRLYLIFEFLSMDL-------------KKYLDSIPPGQYMDSSLVKSYL 109

  Fly   133 YQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTF 197
            ||||.||.:.||..||||||||.|:|:    :::|.:|:||.|.||.|..|::....   .|||.
Human   110 YQILQGIVFCHSRRVLHRDLKPQNLLI----DDKGTIKLADFGLARAFGIPIRVYTH---EVVTL 167

  Fly   198 WYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFP 262
            |||:||:|||:..|:..:|||:||.|||||.|.:|:||...|         .|||.|||..:|.|
Human   168 WYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSE---------IDQLFRIFRALGTP 223

  Fly   263 QDKDWEDIKKMPEHHTLTKDFKRS--TYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRIT 325
            .::.|.:::.:       :|:|.:  .:...|||.:::    ..|.....||.|:|:.||.|||:
Human   224 NNEVWPEVESL-------QDYKNTFPKWKPGSLASHVK----NLDENGLDLLSKMLIYDPAKRIS 277

  Fly   326 SEQAMQDQYFQE 337
            .:.|:...||.:
Human   278 GKMALNHPYFND 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	119/328 (36%)
CDK1	NP_001777.1	STKc_CDK1_euk	3..287	CDD:270845	122/333 (37%)