Protein Alignment Cdk8 and CDC28

DIOPT Version :10

• Sequence 1: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_009718.3
• Gene: CDC28 / 852457
• SGDID: S000000364
• Length: 298
• Species: Saccharomyces cerevisiae
• Alignment Length: 329
• Identity: 121/329 - (36%)
• Similarity: 174/329 - (52%)
• Gaps: 44/329 - (13%)

  Fly    18 DLFNYEGC-KVGRGTYGHVYKAKWKETSDGKE-YALKQI----DGTGLSMSACREIALLRELKHQ 76
            :|.||:.. |||.||||.||||.......|:. .|||:|    :..|:..:|.|||:||:|||..
Yeast     4 ELANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDD 68

  Fly    77 NVITLIRVFLSHND-RKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMVKSLLYQILDGIH 140
            |::.|..:.  |:| .|::|:.::.:.||      .|..:...|...:...:||..:.|:..||.
Yeast    69 NIVRLYDIV--HSDAHKLYLVFEFLDLDL------KRYMEGIPKDQPLGADIVKKFMMQLCKGIA 125

  Fly   141 YLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELL 205
            |.||:.:|||||||.|:|:..|||    :|:.|.|.||.|..||:....   .:||.||||||:|
Yeast   126 YCHSHRILHRDLKPQNLLINKDGN----LKLGDFGLARAFGVPLRAYTH---EIVTLWYRAPEVL 183

  Fly   206 LGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDI 270
            ||.:.|:..:|.|:|||||||:...:|||         |.....||:.:||.|:|.|.:..|.||
Yeast   184 LGGKQYSTGVDTWSIGCIFAEMCNRKPIF---------SGDSEIDQIFKIFRVLGTPNEAIWPDI 239

  Fly   271 KKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKP--DSKAFHLLQKLLLMDPNKRITSEQAMQDQ 333
            ..:|:.......::|...|           ::.|  |.:...||.|||..||..||::.:|....
Yeast   240 VYLPDFKPSFPQWRRKDLS-----------QVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHP 293

  Fly   334 YFQE 337
            ||||
Yeast   294 YFQE 297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	117/324 (36%)
CDC28	NP_009718.3	STKc_CDK1_CdkB_like	8..295	CDD:270829	115/321 (36%)