Protein Alignment Cdk8 and Cdk19

DIOPT Version :9

• Sequence 1: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_001161776.1
• Gene: Cdk19 / 78334
• MGIID: 1925584
• Length: 501
• Species: Mus musculus
• Alignment Length: 491
• Identity: 332/491 - (67%)
• Similarity: 369/491 - (75%)
• Gaps: 40/491 - (8%)

  Fly     1 MDYDFKMKTQIERTKVEDLFNYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQIDGTGLSMSACR 65
            ||||||.|...||.:|||||.|||||||||||||||||:.|:..|.||||||||:|||:||||||
Mouse     1 MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACR 65

  Fly    66 EIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMVKS 130
            ||||||||||.|||.|.:|||||:||||:||.||||||||||||||||:||.||.:.:||.||||
Mouse    66 EIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKS 130

  Fly   131 LLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVV 195
            |||||||||||||:|||||||||||||||||:|.|||||||||||||||||:|||||||||||||
Mouse   131 LLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVV 195

  Fly   196 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMG 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||:|||
Mouse   196 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMG 260

  Fly   261 FPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRIT 325
            ||.|||||||:||||:.||.|||:|:||:..||.||||:||:|||||.|.||||||.|||.||||
Mouse   261 FPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRIT 325

  Fly   326 SEQAMQDQYFQEEPQPTQDVFAGCPIPYPKREFLTDDDQEDKSDNKRQQQQQQQQQQQQQQQQQQ 390
            ||||:||.||||:|.||.||||||.|||||||||.:|:.|:|.|..:.|||...||.....||..
Mouse   326 SEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQPQQQNPHQQPAAPAQQTA 390

  Fly   391 QQQQQQQQQQMNAE-------------------------------PNAK-RVRLSGAGN-----Q 418
            ...|....||.:|:                               ||.| |:..|||.:     .
Mouse   391 APPQAPPPQQSSAQTNGTAGGATAGGGGAGAGLQHSQDPGLNQVPPNKKPRIGPSGANSGGPVMP 455

  Fly   419 QDFHHQQQQQQQQQQQQQQQQQQMMF---NQQQNFQ 451
            .|:.|...:...|...|...|.|...   :.||:.|
Mouse   456 SDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSQQSTQ 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	267/315 (85%)
		S_TKc	22..335	CDD:214567	265/312 (85%)
Cdk19	NP_001161776.1	STKc_CDC2L6	18..335	CDD:270850	268/316 (85%)
		S_TKc	22..335	CDD:214567	265/312 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..501		31/130 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830638
Domainoid	1	1.000	572	1.000	Domainoid score	I228
eggNOG	1	0.900	-	-		E1_KOG0666
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	673	1.000	Inparanoid score	I729
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287471at33208
OrthoFinder	1	1.000	-	-		FOG0002084
OrthoInspector	1	1.000	-	-		otm42337
orthoMCL	1	0.900	-	-		OOG6_102974
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1399
SonicParanoid	1	1.000	-	-		X1379
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790