Protein Alignment Cdk8 and CDK11A

DIOPT Version :10

• Sequence 1: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_001300825.1
• Gene: CDK11A / 728642
• HGNCID: 1730
• Length: 783
• Species: Homo sapiens
• Alignment Length: 333
• Identity: 117/333 - (35%)
• Similarity: 188/333 - (56%)
• Gaps: 47/333 - (14%)

  Fly    23 EGC----------KVGRGTYGHVYKAKWKETSDGKEYALKQI----DGTGLSMSACREIALLREL 73
            :||          ::..||||.||:||.|:|.:  ..|||::    :..|..:::.|||..:.:.
Human   418 QGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDE--IVALKRLKMEKEKEGFPITSLREINTILKA 480

  Fly    74 KHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMVKSLLYQILDG 138
            :|.|::|:..:.:..|..|::::::|.||||       ::...|.||..:| |.||:|:.|:|.|
Human   481 QHPNIVTVREIVVGSNMDKIYIVMNYVEHDL-------KSLMETMKQPFLP-GEVKTLMIQLLRG 537

  Fly   139 IHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPE 203
            :.:||.||:||||||.:|:|:    :..|.:|:.|.|.||.:.:|||...   |||||.||||||
Human   538 VKHLHDNWILHRDLKTSNLLL----SHAGILKVGDFGLAREYGSPLKAYT---PVVVTQWYRAPE 595

  Fly   204 LLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWE 268
            |||||:.|:.|:|:|::||||.||||.:|:|....|         .||::::|..:|.|.:|.|.
Human   596 LLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSE---------IDQINKVFKELGTPSEKIWP 651

  Fly   269 DIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDQ 333
            ...::|.       .|:.|:|........:|.......:.|.|:.|.|...|.:||::|..::.:
Human   652 GYSELPV-------VKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHE 709

  Fly   334 YFQEEPQP 341
            ||:|.|.|
Human   710 YFRETPLP 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	112/325 (34%)
CDK11A	NP_001300825.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	18..396
		STKc_CDC2L1	420..711	CDD:173741	111/323 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	721..783