DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cdk8 and CDK12

DIOPT Version :10

Sequence 1:NP_536735.2 Gene:Cdk8 / 39157 FlyBaseID:FBgn0015618 Length:454 Species:Drosophila melanogaster
Sequence 2:NP_057591.2 Gene:CDK12 / 51755 HGNCID:24224 Length:1490 Species:Homo sapiens


Alignment Length:519 Identity:144/519 - (27%)
Similarity:227/519 - (43%) Gaps:118/519 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 FKMKTQI------ERTKVE--------DLFNYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQI- 54
            :|.:.:|      ||.:.|        |.|:..|. :|.||||.|||||.|:|  |:..|||:: 
Human   698 YKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGI-IGEGTYGQVYKAKDKDT--GELVALKKVR 759

  Fly    55 ---DGTGLSMSACREIALLRELKHQNVITLIRVFLSHNDR--------KVFLLIDYAEHDLWHII 108
               :..|..::|.|||.:||:|.|::|:.:..:.....|.        ..:|:.:|.:|||..::
Human   760 LDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLL 824

  Fly   109 KFHRAAKATKKQVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIAD 173
            :        ...|......:||.:.|:::|:.|.|....||||:|.:|||:    |..|::|:||
Human   825 E--------SGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILL----NNSGQIKLAD 877

  Fly   174 MGFARLFNA-PLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCR 237
            .|.|||:|: ..:|..:   .|:|.|||.||||||...||.|||:|:.|||..||.|.:|||   
Human   878 FGLARLYNSEESRPYTN---KVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIF--- 936

  Fly   238 QEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTL--TKDFKRSTYSTCSLAKYMERH 300
            |.:::.:      ||:.|..:.|.|....|.|:.|:|..:|:  .|.::|         :..|..
Human   937 QANLELA------QLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRR---------RLREEF 986

  Fly   301 KIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDQYFQ----------------------------- 336
            ...| |.|..||..:|.:||:||.|:||.:|..:.:                             
Human   987 SFIP-SAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQ 1050

  Fly   337 -------EEPQPT----QDVFAGC------------PIPYPKREFLTDDDQEDKSDNKRQQQQQQ 378
                   |||.|:    ::..:|.            |.|.|.:......|....:|..:|..|.:
Human  1051 RQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSE 1115

  Fly   379 QQQQQQQQQQQQQQQQQQQQQQMNAEPNAKRVRLSGAGNQQDFHHQQQQQQQQQQQQQQQQQQM 442
            ........|.|......|..|.:|...|.:..:...|.||......:...|||..:....::.:
Human  1116 LAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESL 1179

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cdk8NP_536735.2 STKc_CDK8_like 19..335 CDD:270834 114/330 (35%)
CDK12NP_057591.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..703 1/4 (25%)
STKc_CDK12 719..1020 CDD:270847 115/337 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1047..1098 8/50 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1161..1189 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1220..1348
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1441..1460
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1466..1490
Blue background indicates that the domain is not in the aligned region.

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