Protein Alignment Cdk8 and CDK16

DIOPT Version :10

• Sequence 1: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: XP_011542222.1
• Gene: CDK16 / 5127
• HGNCID: 8749
• Length: 571
• Species: Homo sapiens
• Alignment Length: 358
• Identity: 121/358 - (33%)
• Similarity: 174/358 - (48%)
• Gaps: 61/358 - (17%)

  Fly    26 KVGRGTYGHVYKAKWKETSDGKEYALKQI---DGTGLSMSACREIALLRELKHQNVITLIRVFLS 87
            |:|.|||..|||.|.|.|.:  ..|||:|   ...|...:|.||::||::|||.|::||..:.
Human   244 KLGEGTYATVYKGKSKLTDN--LVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDII-- 304

  Fly    88 HNDRKVFLLIDYAEHDL-------WHIIKFHRAAKATKKQVVVPRGMVKSLLYQILDGIHYLHSN 145
            |.::.:.|:.:|.:.||       .:||..|.               ||..|:|:|.|:.|.|..
Human   305 HTEKSLTLVFEYLDKDLKQYLDDCGNIINMHN---------------VKLFLFQLLRGLAYCHRQ 354

  Fly   146 WVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARH 210
            .||||||||.|:|:    ||||.:|:||.|.||..:.|.|..::   .|||.|||.|::|||:..
Human   355 KVLHRDLKPQNLLI----NERGELKLADFGLARAKSIPTKTYSN---EVVTLWYRPPDILLGSTD 412

  Fly   211 YTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPE 275
            |:..||:|.:||||.|:.|..|:|         ......:||..||.::|.|.::.|..|..
Human   413 YSTQIDMWGVGCIFYEMATGRPLF---------PGSTVEEQLHFIFRILGTPTEETWPGILS--- 465

  Fly   276 HHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDQYF----- 335
                .::||...|.... |:.:..|..:.||....||.|||..:...||::|.||:..:|
Human   466 ----NEEFKTYNYPKYR-AEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGE 525

  Fly   336 --QEEPQPTQDVFAGCPIPYPKREFLTDDDQED 366
              .:.|. |..:||...|...|...|......|
Human   526 RIHKLPD-TTSIFALKEIQLQKEASLRSSSMPD 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	112/318 (35%)
CDK16	XP_011542222.1	STKc_PCTAIRE1	236..532	CDD:270854	113/330 (34%)