Protein Alignment Cdk8 and Cdk12

DIOPT Version :10

• Sequence 1: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Alignment Length: 387
• Identity: 125/387 - (32%)
• Similarity: 190/387 - (49%)
• Gaps: 92/387 - (23%)

  Fly    26 KVGRGTYGHVYKAKWKETSDGKEYALKQI----DGTGLSMSACREIALLRELKHQNVITLIRVFL 86
            ::|.||||.||||:...|:|  ..|||::    :..|..::|.|||.:||:|.|:|::.|..:..
  Fly   809 QIGEGTYGQVYKARDHHTND--MVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVT 871

  Fly    87 SHND----RK----VFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMV-------KSLLYQIL 136
            ...|    ||    .:|:.:|.:|||..:::               .|||       .|::.|:|
  Fly   872 DKQDAVEFRKDKGSFYLVFEYMDHDLMGLLE---------------SGMVDFNEENNASIMKQLL 921

  Fly   137 DGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAP--LKPLADLDPVVVTFWY 199
            ||::|.|....||||:|.:|||:    |.||:||:||.|.|||:||.  .:|..:   .|:|.||
  Fly   922 DGLNYCHKKNFLHRDIKCSNILM----NNRGKVKLADFGLARLYNADDRERPYTN---KVITLWY 979

  Fly   200 RAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQD 264
            |.||||||...|..:||:|:.|||..||....|:|....|         ..||:.|..:.|.|..
  Fly   980 RPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAE---------MAQLETISKICGSPVP 1035

  Fly   265 KDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPD-----SKAFHLLQKLLLMDPNKRI 324
            ..|.::.|:|..|||.:             |...|.:::.|     :.|..||.|:|.:||:|||
  Fly  1036 AVWPNVIKLPLFHTLKQ-------------KKTHRRRLREDFEFMPAPALDLLDKMLDLDPDKRI 1087

  Fly   325 TSEQAMQDQYFQ-----EEPQPTQDVFAGCPIPYPKREFLTDDDQEDKSDNKRQQQQQQQQQ 381
            |:|.|::..:.:     |.|.|....:..|...:.|               ||::|.::||:
  Fly  1088 TAEDALRSPWLRKINPDEMPTPQLPTWQDCHELWSK---------------KRRRQMREQQE 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	115/334 (34%)
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	115/334 (34%)