DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdk8 and cdk8

DIOPT Version :9

Sequence 1:	NP_536735.2	Gene:	Cdk8 / 39157	FlyBaseID:	FBgn0015618	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_989246.1	Gene:	cdk8 / 394856	XenbaseID:	XB-GENE-962267	Length:	464	Species:	Xenopus tropicalis

Alignment Length:	459	Identity:	331/459 - (72%)
Similarity:	362/459 - (78%)	Gaps:	17/459 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDYDFKMKTQIERTKVEDLFNYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQIDGTGLSMSACR 65
            ||||||:|...||.:|||||.||||||||||||||||||.|:..|.::||||||:|||:||||||
Frog     1 MDYDFKVKLTGERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGRDDRDYALKQIEGTGISMSACR 65

  Fly    66 EIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMVKS 130
            ||||||||||.|||:|.:|||||.||||:||.|:||||||||||||||:||.||.|.:|||||||
Frog    66 EIALLRELKHPNVISLQKVFLSHADRKVWLLFDFAEHDLWHIIKFHRASKANKKPVQLPRGMVKS 130

  Fly   131 LLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVV 195
            |||||||||||||:|||||||||||||||||:|.|||||||||||||||||:|||||||||||||
Frog   131 LLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVV 195

  Fly   196 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMG 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   196 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMG 260

  Fly   261 FPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRIT 325
            ||.|||||||||||||.||.|||:|:||:.|||.||||:||:|||||.||||||||.|||.|||:
Frog   261 FPADKDWEDIKKMPEHSTLIKDFRRNTYTNCSLIKYMEKHKVKPDSKTFHLLQKLLTMDPIKRIS 325

  Fly   326 SEQAMQDQYFQEEPQPTQDVFAGCPIPYPKREFLTDDDQEDKSDNKRQQQQQQQQQQQQQQQQQQ 390
            |||||||.||.|:|.||.||||||.||||||||||:::.:||.|.|.|||||.............
Frog   326 SEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGN 390

  Fly   391 QQQQQQQQQQMNAEPNAKRVRL------SG-----AGNQQDFHHQQQQQQQQQQQQQQQQQQMMF 444
            |.....|      .|..|:||:      ||     :..|:...|...|.......|.|.......
Frog   391 QDNSHAQ------GPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYQNPGPSTSQPQSSMGYSS 449

  Fly   445 NQQQ 448
            ..||
Frog   450 TSQQ 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	273/315 (87%)
Cdk8	NP_536735.2	S_TKc	22..335	CDD:214567	271/312 (87%)
cdk8	NP_989246.1	Interaction with CCNC. /evidence=ECO:0000250	1..15		9/13 (69%)
		PKc_like	3..335	CDD:328722	283/331 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..464		24/99 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	564	1.000	Domainoid score	I233
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55565
Inparanoid	1	1.050	670	1.000	Inparanoid score	I739
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287471at33208
OrthoFinder	1	1.000	-	-		FOG0002084
OrthoInspector	1	1.000	-	-		otm47443
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1399
SonicParanoid	1	1.000	-	-		X1379
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.100