Protein Alignment Cdk8 and cdk8

DIOPT Version :10

• Sequence 1: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_989246.1
• Gene: cdk8 / 394856
• XenbaseID: XB-GENE-962267
• Length: 464
• Species: Xenopus tropicalis
• Alignment Length: 459
• Identity: 331/459 - (72%)
• Similarity: 362/459 - (78%)
• Gaps: 17/459 - (3%)

  Fly     1 MDYDFKMKTQIERTKVEDLFNYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQIDGTGLSMSACR 65
            ||||||:|...||.:|||||.||||||||||||||||||.|:..|.::||||||:|||:||||||
 Frog     1 MDYDFKVKLTGERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGRDDRDYALKQIEGTGISMSACR 65

  Fly    66 EIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMVKS 130
            ||||||||||.|||:|.:|||||.||||:||.|:||||||||||||||:||.||.|.:|||||||
 Frog    66 EIALLRELKHPNVISLQKVFLSHADRKVWLLFDFAEHDLWHIIKFHRASKANKKPVQLPRGMVKS 130

  Fly   131 LLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVV 195
            |||||||||||||:|||||||||||||||||:|.|||||||||||||||||:|||||||||||||
 Frog   131 LLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVV 195

  Fly   196 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMG 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   196 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMG 260

  Fly   261 FPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRIT 325
            ||.|||||||||||||.||.|||:|:||:.|||.||||:||:|||||.||||||||.|||.|||:
 Frog   261 FPADKDWEDIKKMPEHSTLIKDFRRNTYTNCSLIKYMEKHKVKPDSKTFHLLQKLLTMDPIKRIS 325

  Fly   326 SEQAMQDQYFQEEPQPTQDVFAGCPIPYPKREFLTDDDQEDKSDNKRQQQQQQQQQQQQQQQQQQ 390
            |||||||.||.|:|.||.||||||.||||||||||:::.:||.|.|.|||||.............
 Frog   326 SEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGN 390

  Fly   391 QQQQQQQQQQMNAEPNAKRVRL------SG-----AGNQQDFHHQQQQQQQQQQQQQQQQQQMMF 444
            |.....|      .|..|:||:      ||     :..|:...|...|.......|.|.......
 Frog   391 QDNSHAQ------GPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYQNPGPSTSQPQSSMGYSS 449

  Fly   445 NQQQ 448
            ..||
 Frog   450 TSQQ 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	273/315 (87%)
cdk8	NP_989246.1	Interaction with CCNC. /evidence=ECO:0000250	1..15		9/13 (69%)
		Protein Kinases, catalytic domain	3..335	CDD:473864	283/331 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	361..464		24/99 (24%)