Protein Alignment Cdk8 and Cdk4

DIOPT Version :9

• Sequence 1: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_001286493.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Alignment Length: 356
• Identity: 118/356 - (33%)
• Similarity: 179/356 - (50%)
• Gaps: 71/356 - (19%)

  Fly    10 QIERTKVE--------DLFNYEGCK-VGRGTYGHVYKAKWKETSDGKEYALKQI----DGTGLSM 61
            |::|.|:.        |.|||:... :|.|.||.||:|  ::...|...|||::    :..|:.|
  Fly     6 QLKRQKMSQAKKFGDGDPFNYQELNIIGEGAYGTVYRA--RDVITGNIVALKKVRISLNENGVPM 68

  Fly    62 SACREIALLREL---KHQNVITLIRV--FLSHNDRKVFLLI-DYAEHDLWHIIKFHRAAKATKKQ 120
            |..|||:||::|   .|.|::.|..|  ||..:.:.:.||: ::.|.||..:|  .|..|:....
  Fly    69 STLREISLLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLI--DRLPKSGMSP 131

  Fly   121 VVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLK 185
            ..:.|     |..::|.|:.:|||:.::||||||.|:||    :.:|.:||||.|.|:.:.:.:|
  Fly   132 PTIQR-----LSRELLTGVDFLHSHRIIHRDLKPQNLLV----SSQGHLKIADFGLAKTYGSEMK 187

  Fly   186 PLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHD 250
                |..||||.||||||:|| |:.|...:|||:..||..|:.....:|....|         .:
  Fly   188 ----LTSVVVTLWYRAPEVLL-AQPYNSTVDIWSAACIIFEMFNRRALFPGTSE---------KN 238

  Fly   251 QLDRIFNVMGFPQDKDWED-----IKKMPEHH-TLTKDFKRSTYSTC-SLAKYMERHKIKPDSKA 308
            ||||||.:.|.|.::.|..     ::..|:.| ...|||       | .|.||           |
  Fly   239 QLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPKDF-------CPHLCKY-----------A 285

  Fly   309 FHLLQKLLLMDPNKRITSEQAMQDQYFQEEP 339
            ..||.|:|..|.:.|.::...::..|||:||
  Fly   286 DDLLNKMLSYDLHLRPSALACLEHDYFQQEP 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	109/333 (33%)
		S_TKc	22..335	CDD:214567	107/330 (32%)
Cdk4	NP_001286493.1	STKc_CDK4_6_like	26..312	CDD:270831	107/330 (32%)
		S_TKc	26..312	CDD:214567	107/330 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442411
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24056
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030