Protein Alignment Cdk8 and Cdk2

DIOPT Version :10

• Sequence 1: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: XP_562342.4
• Gene: Cdk2 / 3291042
• VectorBaseID: AGAMI1_009397
• Length: 309
• Species: Anopheles gambiae
• Alignment Length: 343
• Identity: 116/343 - (33%)
• Similarity: 181/343 - (52%)
• Gaps: 54/343 - (15%)

  Fly     1 MDYDFKMKTQIERTKVEDLFNYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQI----DGTGLSM 61
            :.|:.:...:::|..|.|..:    |:|.||||.|||||...|.:  ..|||:|    :..|:..
Mosquito     3 LKYNIEDAQKMQRVGVYDRVD----KIGEGTYGVVYKAKDIRTQN--YVALKRIRLDNETEGIPS 61

  Fly    62 SACREIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRG 126
            :|.|||:||::|||.:::.|..|.:.  |..::::.:|.:.||..::..|:::       ..|.
Mosquito    62 TAMREISLLKDLKHHSIVELFDVVII--DASIYMVFEYLDMDLKKMLDRHKSS-------FTPM- 116

  Fly   127 MVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLD 191
            :|||.::|:||.|.|.|.|.:|||||||.|:|:    :..|.:|:||.|.||..|.|::....
Mosquito   117 LVKSYMHQMLDAIAYCHLNRILHRDLKPQNLLI----DREGHIKLADFGLARAVNFPIRVYTH-- 175

  Fly   192 PVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIF 256
             .|||.||||||:|||.:.|...:|.|::||||||::...|:|....|         .|||.:||
Mosquito   176 -EVVTLWYRAPEILLGTKFYCVGVDTWSLGCIFAEMILKRPLFPGDSE---------IDQLFKIF 230

  Fly   257 NVMGFPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYME----RHKIKPDSKAFHLLQKLLL 317
            ..||.|.:..|..:..:       .|:|.|       ..|.|    .::::.|..|..|..:|:.
Mosquito   231 RQMGTPDETKWPGVSHL-------SDYKES-------FPYWEPQPLPNEMQHDLDAHTLFCELMH 281

  Fly   318 MDPNKRITSEQAMQDQYF 335
            .||.||::.:.||...||
Mosquito   282 YDPTKRLSPKSAMSHSYF 299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	110/323 (34%)
Cdk2	XP_562342.4	Protein Kinases, catalytic domain	19..299	CDD:473864	111/325 (34%)