DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk8 and Cdk19

DIOPT Version :9

Sequence 1:	NP_536735.2	Gene:	Cdk8 / 39157	FlyBaseID:	FBgn0015618	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001101104.1	Gene:	Cdk19 / 309804	RGDID:	1305435	Length:	501	Species:	Rattus norvegicus

Alignment Length:	478	Identity:	330/478 - (69%)
Similarity:	365/478 - (76%)	Gaps:	37/478 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDYDFKMKTQIERTKVEDLFNYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQIDGTGLSMSACR 65
            ||||||.|...||.:|||||.|||||||||||||||||:.|:..|.||||||||:|||:||||||
  Rat     1 MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACR 65

  Fly    66 EIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMVKS 130
            ||||||||||.|||.|.:|||||:||||:||.||||||||||||||||:||.||.:.:||.||||
  Rat    66 EIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKS 130

  Fly   131 LLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVV 195
            |||||||||||||:|||||||||||||||||:|.|||||||||||||||||:|||||||||||||
  Rat   131 LLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVV 195

  Fly   196 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMG 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||:|||
  Rat   196 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMG 260

  Fly   261 FPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRIT 325
            ||.|||||||:||||:.||.|||:|:||:..||.||||:||:|||||.|.||||||.|||.||||
  Rat   261 FPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRIT 325

  Fly   326 SEQAMQDQYFQEEPQPTQDVFAGCPIPYPKREFLTDDDQEDKSDNKRQQQQQQQQQQQQQQQQQQ 390
            ||||:||.||||:|.||.||||||.|||||||||.:|:.|:|.|..:.|||...||....|||..
  Rat   326 SEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQPQQQNPHQQPVAPQQQAA 390

  Fly   391 QQQQQQQQQQMNAE-------------------------------PNAK-RVRLSGAGN-----Q 418
            ...|....||.:|:                               ||.| |:..|||.:     .
  Rat   391 APTQAPPPQQSSAQTNGTAGGATTGGGAAGAGLQHSQDSGLNQVPPNKKPRIGPSGANSGGPVMP 455

  Fly   419 QDFHHQQQQQQQQQQQQQQQQQQ 441
            .|:.|...:...|...|...|.|
  Rat   456 SDYQHSSSRLNYQSSVQGSSQSQ 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	267/315 (85%)
Cdk8	NP_536735.2	S_TKc	22..335	CDD:214567	265/312 (85%)
Cdk19	NP_001101104.1	STKc_CDC2L6	18..335	CDD:270850	268/316 (85%)
Cdk19	NP_001101104.1	S_TKc	22..335	CDD:214567	265/312 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334356
Domainoid	1	1.000	550	1.000	Domainoid score	I245
eggNOG	1	0.900	-	-		E1_KOG0666
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	660	1.000	Inparanoid score	I734
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287471at33208
OrthoFinder	1	1.000	-	-		FOG0002084
OrthoInspector	1	1.000	-	-		oto95465
orthoMCL	1	0.900	-	-		OOG6_102974
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1379
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760