Protein Alignment Cdk8 and Cdk8

DIOPT Version :9

• Sequence 1: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_705827.2
• Gene: Cdk8 / 264064
• MGIID: 1196224
• Length: 464
• Species: Mus musculus
• Alignment Length: 412
• Identity: 325/412 - (78%)
• Similarity: 353/412 - (85%)
• Gaps: 6/412 - (1%)

  Fly     1 MDYDFKMKTQIERTKVEDLFNYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQIDGTGLSMSACR 65
            ||||||:|...||.:|||||.||||||||||||||||||.|:..|.|:||||||:|||:||||||
Mouse     1 MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACR 65

  Fly    66 EIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMVKS 130
            ||||||||||.|||:|::|||||.||||:||.||||||||||||||||:||.||.|.:|||||||
Mouse    66 EIALLRELKHPNVISLLKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKS 130

  Fly   131 LLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVV 195
            |||||||||||||:|||||||||||||||||:|.|||||||||||||||||:|||||||||||||
Mouse   131 LLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVV 195

  Fly   196 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMG 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMG 260

  Fly   261 FPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRIT 325
            ||.|||||||||||||.||.|||:|:||:.|||.||||:||:||||||||||||||.|||.||||
Mouse   261 FPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRIT 325

  Fly   326 SEQAMQDQYFQEEPQPTQDVFAGCPIPYPKREFLTDDDQEDKSDNKRQQQQQQQQQQQQQQQQQQ 390
            |||||||.||.|:|.||.||||||.||||||||||:::.::|.|.|.|||||.............
Mouse   326 SEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDEKGDKKTQQQQQGNNHTNGTGHPGN 390

  Fly   391 QQQQQQQQQQMNAEPNAKRVRL 412
            |.....|      .|..|:||:
Mouse   391 QDSGHAQ------GPPLKKVRV 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	277/315 (88%)
		S_TKc	22..335	CDD:214567	275/312 (88%)
Cdk8	NP_705827.2	Interaction with CCNC. /evidence=ECO:0000250	1..15		9/13 (69%)
		STKc_CDK8	3..335	CDD:270851	287/331 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	358..464		17/55 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	572	1.000	Domainoid score	I228
eggNOG	1	0.900	-	-		E1_KOG0666
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55565
Inparanoid	1	1.050	673	1.000	Inparanoid score	I729
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002084
OrthoInspector	1	1.000	-	-		otm42337
orthoMCL	1	0.900	-	-		OOG6_102974
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1399
SonicParanoid	1	1.000	-	-		X1379
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.850