Protein Alignment Cdk8 and CDK19

DIOPT Version :10

• Sequence 1: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_055891.1
• Gene: CDK19 / 23097
• HGNCID: 19338
• Length: 502
• Species: Homo sapiens
• Alignment Length: 489
• Identity: 334/489 - (68%)
• Similarity: 369/489 - (75%)
• Gaps: 37/489 - (7%)

  Fly     1 MDYDFKMKTQIERTKVEDLFNYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQIDGTGLSMSACR 65
            ||||||.|...||.:|||||.|||||||||||||||||:.|:..|.||||||||:|||:||||||
Human     1 MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACR 65

  Fly    66 EIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMVKS 130
            ||||||||||.|||.|.:|||||:||||:||.||||||||||||||||:||.||.:.:||.||||
Human    66 EIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKS 130

  Fly   131 LLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVV 195
            |||||||||||||:|||||||||||||||||:|.|||||||||||||||||:|||||||||||||
Human   131 LLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVV 195

  Fly   196 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMG 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||:|||
Human   196 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMG 260

  Fly   261 FPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRIT 325
            ||.|||||||:||||:.||.|||:|:||:..||.||||:||:|||||.|.||||||.|||.||||
Human   261 FPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRIT 325

  Fly   326 SEQAMQDQYFQEEPQPTQDVFAGCPIPYPKREFLTDDDQEDKSDNKRQQQQQQQQQ--------- 381
            ||||:||.||||:|.||.||||||.|||||||||.:||.|:|.|..:||||.|.||
Human   326 SEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAA 390

  Fly   382 ---QQQQQQQQQQQQ------------------QQQQQQQMNAEPNAKRVRL--SGAGN-----Q 418
               |....||...|.                  |..|...:|..|..|:.||  |||.:     .
Human   391 APPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMP 455

  Fly   419 QDFHHQQQQQQQQQQQQQQQQQQMMFNQQQNFQR 452
            .|:.|...:...|...|...|.|.......:.|:
Human   456 SDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQ 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	267/315 (85%)
CDK19	NP_055891.1	STKc_CDC2L6	18..335	CDD:270850	268/316 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	359..502		34/131 (26%)