Protein Alignment Cdk8 and dyf-18

DIOPT Version :10

• Sequence 1: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_502232.2
• Gene: dyf-18 / 186662
• WormBaseID: WBGene00010349
• Length: 323
• Species: Caenorhabditis elegans
• Alignment Length: 347
• Identity: 118/347 - (34%)
• Similarity: 173/347 - (49%)
• Gaps: 48/347 - (13%)

  Fly    19 LFNYEGCKV-GRGTYGHVYKAKWKETSDGKEYALKQIDGTGLS-MSACREIALLRELKHQNVITL 81
            ::.||..:| |||.:|.|..|  ::|...|..|:|:|....:| :|..|||:.||.|.|:|::.|
 Worm     5 IYRYETIQVAGRGAFGLVVIA--RDTLTSKRVAIKRIMVPNVSKVSLAREISCLRNLHHRNILKL 67

  Fly    82 IRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMVKSLLYQILDGIHYLHSNW 146
            :..|.|.:  .:.::.:...:.|..|||.....|..:        ..:....|||.||.||||..
 Worm    68 LDCFPSAD--LMSIVTEEVPYTLGDIIKDKTRPKTEQ--------FNRWYYTQILSGIAYLHSKE 122

  Fly   147 VLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHY 211
            ::|||:||.||||    ..|..|||||.|.| .|..|..|..:.|..|.|.||||||||.|::.|
 Worm   123 IMHRDIKPENILV----TSRNVVKIADFGQA-CFYMPKDPNQEYDVNVATRWYRAPELLFGSKKY 182

  Fly   212 TKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEH 276
            ...:||||||||.|||:..:|||..|.|         .:|:..||.|:|.|.:.:|.:.:.||:.
 Worm   183 KPDVDIWAIGCILAELVRGKPIFPGRSE---------LEQISIIFGVLGTPNEDNWPNWRTMPDA 238

  Fly   277 HTLTKDFK--RSTYSTCSLAK---------------YMERHKIKPDSKAFHLLQKLLLMDPNKRI 324
            :.|..:.|  |:.::...|.|               :.:|.|.....|...:.|.|.|::||.||
 Worm   239 NKLLFEPKEPRNNWTEILLCKEISNNFTEFLGSHLQFFKRLKASELLKEPWIKQGLPLVEPNYRI 303

  Fly   325 TSEQAMQDQYFQEEPQPTQDVF 346
            :.:...::   |.:..|...||
 Worm   304 SKKSTRRN---QRDALPPLHVF 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	114/334 (34%)
dyf-18	NP_502232.2	Protein Kinases, catalytic domain	7..289	CDD:473864	107/307 (35%)