DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk8 and cdk-8

DIOPT Version :9

Sequence 1:	NP_536735.2	Gene:	Cdk8 / 39157	FlyBaseID:	FBgn0015618	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_492357.2	Gene:	cdk-8 / 172677	WormBaseID:	WBGene00000409	Length:	588	Species:	Caenorhabditis elegans

Alignment Length:	465	Identity:	258/465 - (55%)
Similarity:	325/465 - (69%)	Gaps:	26/465 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDYDFKMKTQIERTKVEDLFNYEGCK-VGRGTYGHVYKAKWKETS---DGKEYALKQIDGTGLSM 61
            :|.:||.:....|.:|||||.:|..| :||||||.||||..|:.:   ..||||||.|:|.|.||
Worm     5 IDENFKKQLAQRRERVEDLFYFENSKEIGRGTYGLVYKAVPKKQNGQFPNKEYALKMIEGQGFSM 69

  Fly    62 SACREIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRG 126
            ||||||||.|||:|.|:|.|.||||: |::||:||:|||||||||:||.||.||:.|..::|||.
Worm    70 SACREIALFRELRHPNLICLQRVFLT-NEKKVWLLLDYAEHDLWHVIKHHRTAKSKKVPIMVPRN 133

  Fly   127 MVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDG--NERGRVKIADMGFARLFNAPLKPLAD 189
            |||::|:|||.|:|||||||||||||||||||:||||  :.||||||||:||:|::..||||:|:
Worm   134 MVKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGPPDMRGRVKIADLGFSRIYANPLKPMAE 198

  Fly   190 LDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDR 254
            |||||||||||||||||||:|||||||:||||||||||||:||:|.|::||||..||||:||:.|
Worm   199 LDPVVVTFWYRAPELLLGAKHYTKAIDVWAIGCIFAELLTAEPLFFCKEEDIKAQNPYHYDQVKR 263

  Fly   255 IFNVMGFPQDKDWEDIKKMPEHHTLTKDFKR-----STYSTCSLAKYMERHKIKPDSKAFHLLQK 314
            ||:::|:|.|.||.|:||||:|..|..|.:.     .|:.. ||.:|.::.||...|..:.||.|
Worm   264 IFHLLGYPSDADWPDMKKMPDHQRLLSDARNEGTPIQTFPN-SLHRYFDKWKINSQSSPYRLLVK 327

  Fly   315 LLLMDPNKRITSEQAMQDQYF---QEEPQPTQDVFAGCPIPYPKREFLTDDDQEDKSDNKRQQQQ 376
            ||.:||.||::.|:||.|.||   :..|:.|.|||...||||.|:|     .|...:.::.|||.
Worm   328 LLTVDPTKRVSCEEAMNDIYFRKMERPPRETDDVFNKYPIPYAKKE-----QQMTVAPDQAQQQH 387

  Fly   377 QQQQQQQQQQQQQQQQQQQQQQQQMNAEPNAKRVRLSGAGN---QQDFHHQQQQQQQQQQQQQQQ 438
            ||||.|.|||.|..|||...|.|.:  :|...:..:.||..   ..|.|..|..||||..||...
Worm   388 QQQQVQMQQQPQMGQQQMMGQPQMV--QPQMGQPPMGGAHPGVVAPDGHPHQMMQQQQHPQQHHM 450

  Fly   439 QQQMMFNQQQ 448
            |.|.|.:..|
Worm   451 QYQGMHDPMQ 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	204/326 (63%)
Cdk8	NP_536735.2	S_TKc	22..335	CDD:214567	202/323 (63%)
cdk-8	NP_492357.2	STKc_CDK8_like	26..348	CDD:270834	202/323 (63%)
cdk-8	NP_492357.2	S_TKc	26..348	CDD:214567	202/323 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	416	1.000	Domainoid score	I328
eggNOG	1	0.900	-	-		E1_KOG0666
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55565
Inparanoid	1	1.050	489	1.000	Inparanoid score	I779
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53505
OrthoDB	1	1.010	-	-		D287471at33208
OrthoFinder	1	1.000	-	-		FOG0002084
OrthoInspector	1	1.000	-	-		oto18366
orthoMCL	1	0.900	-	-		OOG6_102974
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1399
SonicParanoid	1	1.000	-	-		X1379
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.870