Protein Alignment Cdk8 and Cdk6

DIOPT Version :10

• Sequence 1: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_034003.1
• Gene: Cdk6 / 12571
• MGIID: 1277162
• Length: 326
• Species: Mus musculus
• Alignment Length: 329
• Identity: 114/329 - (34%)
• Similarity: 177/329 - (53%)
• Gaps: 52/329 - (15%)

  Fly    22 YEGC--KVGRGTYGHVYKAKWKETSDGKEYALK----QIDGTGLSMSACREIALLREL---KHQN 77
            || |  ::|.|.||.|:||: ...:.|:..|||    |....|:.:|..||:|:||.|   :|.|
Mouse    13 YE-CVAEIGEGAYGKVFKAR-DLKNGGRFVALKRVRVQTSEEGMPLSTIREVAVLRHLETFEHPN 75

  Fly    78 VITLIRV-FLSHNDR--KVFLLIDYAEHDL-WHIIKFHRAAKATKKQVVVPRGMVKSLLYQILDG 138
            |:.|..| .:|..||  |:.|:.::.:.|| .::.|.....        ||...:|.:::|:|.|
Mouse    76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG--------VPTETIKDMMFQLLRG 132

  Fly   139 IHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPE 203
            :.:|||:.|:||||||.||||    ...|::|:||.|.||:::..:.    |..||||.||||||
Mouse   133 LDFLHSHRVVHRDLKPQNILV----TSSGQIKLADFGLARIYSFQMA----LTSVVVTLWYRAPE 189

  Fly   204 LLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWE 268
            :||.: .|...:|:|::||||||:...:|:|. ...|:        |||.:|.:::|.|.::||.
Mouse   190 VLLQS-SYATPVDLWSVGCIFAEMFRRKPLFR-GSSDV--------DQLGKILDIIGLPGEEDWP 244

  Fly   269 DIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDQ 333
            ....:|          |..:.:.| |:.:|:.....|.....||.|.|..:|.|||::..|:...
Mouse   245 RDVALP----------RQAFHSKS-AQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYGALNHP 298

  Fly   334 YFQE 337
            |||:
Mouse   299 YFQD 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	111/325 (34%)
Cdk6	NP_034003.1	STKc_CDK6	11..300	CDD:270846	111/325 (34%)