Protein Alignment Cdk8 and Cdk5

DIOPT Version :10

• Sequence 1: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_031694.1
• Gene: Cdk5 / 12568
• MGIID: 101765
• Length: 292
• Species: Mus musculus
• Alignment Length: 326
• Identity: 124/326 - (38%)
• Similarity: 181/326 - (55%)
• Gaps: 60/326 - (18%)

  Fly    26 KVGRGTYGHVYKAKWKETSDGKEYALKQI----DGTGLSMSACREIALLRELKHQNVITLIRVFL 86
            |:|.||||.|:|||.:||.:  ..|||::    |..|:..||.|||.||:||||:|::.|..|.
Mouse     9 KIGEGTYGTVFKAKNRETHE--IVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVL- 70

  Fly    87 SHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRG-----MVKSLLYQILDGIHYLHSNW 146
             |:|:|:.|:.::.:.||             ||......|     :|||.|:|:|.|:.:.||..
Mouse    71 -HSDKKLTLVFEFCDQDL-------------KKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121

  Fly   147 VLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHY 211
            ||||||||.|:|:    |..|.:|:||.|.||.|..|::..:   ..|||.|||.|::|.||:.|
Mouse   122 VLHRDLKPQNLLI----NRNGELKLADFGLARAFGIPVRCYS---AEVVTLWYRPPDVLFGAKLY 179

  Fly   212 TKAIDIWAIGCIFAELLTS-EPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPE 275
            :.:||:|:.|||||||..: .|:|.....|         |||.|||.::|.|.::.|..:.|:|
Mouse   180 STSIDMWSAGCIFAELANAGRPLFPGNDVD---------DQLKRIFRLLGTPTEEQWPAMTKLP- 234

  Fly   276 HHTLTKDFKRSTY----STCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDQYFQ 336
                  |:|  .|    :|.||...:.    |.::....|||.||..:|.:||::|:|:|..||.
Mouse   235 ------DYK--PYPMYPATTSLVNVVP----KLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287

  Fly   337 E 337
            :
Mouse   288 D 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	122/322 (38%)
Cdk5	NP_031694.1	STKc_CDK5	3..286	CDD:143344	122/322 (38%)