Protein Alignment Cdk8 and CDK6

DIOPT Version :10

• Sequence 1: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_001250.1
• Gene: CDK6 / 1021
• HGNCID: 1777
• Length: 326
• Species: Homo sapiens
• Alignment Length: 332
• Identity: 116/332 - (34%)
• Similarity: 176/332 - (53%)
• Gaps: 58/332 - (17%)

  Fly    22 YEGC--KVGRGTYGHVYKAKWKETSDGKEYALK----QIDGTGLSMSACREIALLREL---KHQN 77
            || |  ::|.|.||.|:||: ...:.|:..|||    |....|:.:|..||:|:||.|   :|.|
Human    13 YE-CVAEIGEGAYGKVFKAR-DLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75

  Fly    78 VITLIRV-FLSHNDR--KVFLLIDYAEHDLWHIIKFHRAAKATKKQVV----VPRGMVKSLLYQI 135
            |:.|..| .:|..||  |:.|:.::.:.||           .|....|    ||...:|.:::|:
Human    76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDL-----------TTYLDKVPEPGVPTETIKDMMFQL 129

  Fly   136 LDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYR 200
            |.|:.:|||:.|:||||||.||||    ...|::|:||.|.||:::..:.    |..||||.|||
Human   130 LRGLDFLHSHRVVHRDLKPQNILV----TSSGQIKLADFGLARIYSFQMA----LTSVVVTLWYR 186

  Fly   201 APELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDK 265
            |||:||.: .|...:|:|::||||||:...:|:|. ...|:        |||.:|.:|:|.|.::
Human   187 APEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFR-GSSDV--------DQLGKILDVIGLPGEE 241

  Fly   266 DWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAM 330
            ||.....:|          |..:.:.| |:.:|:.....|.....||.|.|..:|.|||::..|:
Human   242 DWPRDVALP----------RQAFHSKS-AQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295

  Fly   331 QDQYFQE 337
            ...|||:
Human   296 SHPYFQD 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	113/328 (34%)
CDK6	NP_001250.1	STKc_CDK6	11..300	CDD:270846	113/328 (34%)