Protein Alignment Cdk8 and CDK3

DIOPT Version :10

• Sequence 1: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_001249.1
• Gene: CDK3 / 1018
• HGNCID: 1772
• Length: 305
• Species: Homo sapiens
• Alignment Length: 338
• Identity: 131/338 - (38%)
• Similarity: 195/338 - (57%)
• Gaps: 61/338 - (18%)

  Fly    15 KVEDLFNYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQI----DGTGLSMSACREIALLRELKH 75
            |||        |:|.||||.|||||.:||  |:..|||:|    :..|:..:|.|||:||:||||
Human     6 KVE--------KIGEGTYGVVYKAKNRET--GQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60

  Fly    76 QNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMVKSLLYQILDGIH 140
            .|::.|:.|.  ||:||::|:.::...||   .|:..:...::    :|..::||.|:|:|.|:.
Human    61 PNIVRLLDVV--HNERKLYLVFEFLSQDL---KKYMDSTPGSE----LPLHLIKSYLFQLLQGVS 116

  Fly   141 YLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELL 205
            :.||:.|:||||||.|:|:    ||.|.:|:||.|.||.|..||:....   .|||.||||||:|
Human   117 FCHSHRVIHRDLKPQNLLI----NELGAIKLADFGLARAFGVPLRTYTH---EVVTLWYRAPEIL 174

  Fly   206 LGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDI 270
            ||::.||.|:|||:|||||||::|.:.:|....|         .|||.|||.::|.|.:..|..:
Human   175 LGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSE---------IDQLFRIFRMLGTPSEDTWPGV 230

  Fly   271 KKMPEHHTLTKDFKRSTYSTCSLAKYMER------HKIKPDSKAFHLLQKLLLMDPNKRITSEQA 329
            .::|       |:|.      |..|:..:      ..::|:.:  .||.:||..||::|||::.|
Human   231 TQLP-------DYKG------SFPKWTRKGLEEIVPNLEPEGR--DLLMQLLQYDPSQRITAKTA 280

  Fly   330 MQDQYFQE-EPQP 341
            :...||.. ||.|
Human   281 LAHPYFSSPEPSP 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	123/325 (38%)
CDK3	NP_001249.1	STKc_CDK2_3	3..286	CDD:270844	126/329 (38%)