Protein Alignment Cdk8 and CDK2

DIOPT Version :10

• Sequence 1: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: XP_011536034.1
• Gene: CDK2 / 1017
• HGNCID: 1771
• Length: 346
• Species: Homo sapiens
• Alignment Length: 372
• Identity: 128/372 - (34%)
• Similarity: 189/372 - (50%)
• Gaps: 82/372 - (22%)

  Fly    15 KVEDLFNYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQI----DGTGLSMSACREIALLRELKH 75
            |||        |:|.||||.||||:.|.|  |:..|||:|    :..|:..:|.|||:||:||.|
Human     6 KVE--------KIGEGTYGVVYKARNKLT--GEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60

  Fly    76 QNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMVKSLLYQILDGIH 140
            .|::.|:.|.  |.:.|::|:.::...||   .||..|:..|.    :|..::||.|:|:|.|:.
Human    61 PNIVKLLDVI--HTENKLYLVFEFLHQDL---KKFMDASALTG----IPLPLIKSYLFQLLQGLA 116

  Fly   141 YLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELL 205
            :.||:.||||||||.|:|:    |..|.:|:||.|.||.|..|::....   .|||.||||||:|
Human   117 FCHSHRVLHRDLKPQNLLI----NTEGAIKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEIL 174

  Fly   206 LGARHYTKAIDIWAIGCIFAELLTSEPIFHCR---------QEDI------------------KT 243
            ||.::|:.|:|||::||||||:.......|.|         ::.:                  ..
Human   175 LGCKYYSTAVDIWSLGCIFAEMHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTAV 239

  Fly   244 SNPY------------HHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKY 296
            |.||            ..|||.|||..:|.|.:..|..:..||::......:.|..:|
Human   240 STPYPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFS------- 297

  Fly   297 MERHKIKP--DSKAFHLLQKLLLMDPNKRITSEQAMQDQYFQEEPQP 341
                |:.|  |.....||.::|..||||||:::.|:...:||:..:|
Human   298 ----KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	122/360 (34%)
CDK2	XP_011536034.1	STKc_CDK2_3	3..334	CDD:270844	125/364 (34%)