Protein Alignment I-2 and Ppp1r2

DIOPT Version :9

• Sequence 1: NP_001097564.1
• Gene: I-2 / 39156
• FlyBaseID: FBgn0028429
• Length: 310
• Species: Drosophila melanogaster
• Sequence 2: NP_620178.1
• Gene: Ppp1r2 / 192361
• RGDID: 621099
• Length: 205
• Species: Rattus norvegicus
• Alignment Length: 186
• Identity: 74/186 - (39%)
• Similarity: 105/186 - (56%)
• Gaps: 25/186 - (13%)

  Fly   115 PCKGILKTSRSFDKSGAS-------------FRKSAKFDELNVMQTFHPADKDYGHMKIDEPKTP 166
            |.|||||...|...|..:             .:||.|:||:|::.|:||||||||.||||||.||
  Rat    10 PIKGILKNKTSTTSSVVASAEQPRRTVEEELSKKSQKWDEMNILATYHPADKDYGLMKIDEPDTP 74

  Fly   167 YNYTEGFDEN-------RDELDTELLVEKLRIAANTQPSTESIEDDGSSGDDQPLSEEERQRRRE 224
            |:...|.||:       .:.:..|:|.:||..|..::|...:.|.:.|..:|..||.|||:::|:
  Rat    75 YHNMIGDDEDVCSDSEGNEVMTPEILAKKLAAAEGSEPKFRTREQESSGEEDNDLSPEEREKKRQ 139

  Fly   225 FERRRKAHYREFEAVKLARKLIQEE-DDDDDDEDKG----ADSRPSGSSQGASSSG 275
            ||.:||.||.|...:||||:||.:: .|||:||:..    |||.....|...|::|
  Rat   140 FEMKRKLHYNEGLNIKLARQLISKDLHDDDEDEEMSETADADSMNIEESNQGSTAG 195

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
I-2	NP_001097564.1	IPP-2	137..247	CDD:282789	52/116 (45%)
Ppp1r2	NP_620178.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		8/33 (24%)
		Required for binding PPP1CC. /evidence=ECO:0000250	12..17		4/4 (100%)
		Required for binding PPP1CC. /evidence=ECO:0000250	43..55		6/11 (55%)
		IPP-2	45..163	CDD:282789	53/117 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	104..142		13/37 (35%)
		Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activity. /evidence=ECO:0000250	147..150		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..205		11/33 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I5950
eggNOG	1	0.900	-	-		E1_KOG4041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	124	1.000	Inparanoid score	I4627
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1321970at2759
OrthoFinder	1	1.000	-	-		FOG0003529
OrthoInspector	1	1.000	-	-		mtm9103
orthoMCL	1	0.900	-	-		OOG6_106897
Panther	1	1.100	-	-	LDO	PTHR12398
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2894
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830