Protein Alignment I-2 and PPP1R2B

DIOPT Version :10

• Sequence 1: NP_001097564.1
• Gene: I-2 / 39156
• FlyBaseID: FBgn0028429
• Length: 310
• Species: Drosophila melanogaster
• Sequence 2: NP_996740.2
• Gene: PPP1R2B / 153743
• HGNCID: 16318
• Length: 205
• Species: Homo sapiens
• Alignment Length: 200
• Identity: 79/200 - (39%)
• Similarity: 109/200 - (54%)
• Gaps: 32/200 - (16%)

  Fly   115 PCKGILKTS---------------RSFDKSGASFRKSAKFDELNVMQTFHPADKDYGHMKIDEPK 164
            |.|||||..               ||.|:..:  :||.|:||:|::.|:|||||.||.||||||.
Human    10 PIKGILKNKTSTTSSMVASAEQPRRSVDEELS--KKSQKWDEINILATYHPADKGYGLMKIDEPS 72

  Fly   165 TPYNYTEGFDEN--RDELDTE-----LLVEKLRIAANTQPSTESIEDDGSSGDDQPLSEEERQRR 222
            .||:...|.||:  ||...||     :|.:||..|...:|.....|.:.|..:|..||.|||:::
Human    73 PPYHSMMGDDEDACRDTETTEAMAPDILAKKLAAAEGLEPKYRIQEQESSGEEDSDLSPEEREKK 137

  Fly   223 REFERRRKAHYREFEAVKLARKLIQEE-DDDDDDED-----KGADSRPSGSSQGASSSGRFASSS 281
            |:||.|||.||.|...:||||:||.:: .|||:||:     .|.......|:||::.|.:  ..:
Human   138 RQFEMRRKLHYNEGLNIKLARQLISKDLHDDDEDEEMLETADGESMNTEESNQGSTPSDQ--QQN 200

  Fly   282 TKRSS 286
            ..|||
Human   201 KLRSS 205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
I-2	NP_001097564.1	IPP-2	137..244	CDD:461504	52/113 (46%)
PPP1R2B	NP_996740.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		9/35 (26%)
		Required for binding PPP1CC. /evidence=ECO:0000250	12..17		4/4 (100%)
		Required for binding PPP1CC. /evidence=ECO:0000250	43..55		6/11 (55%)
		IPP-2	45..164	CDD:461504	55/118 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..142		11/30 (37%)
		Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activity. /evidence=ECO:0000250	147..150		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..205		11/43 (26%)