DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43897 and CG3376

DIOPT Version :9

Sequence 1:	NP_001261659.1	Gene:	CG43897 / 39153	FlyBaseID:	FBgn0264489	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_001246491.1	Gene:	CG3376 / 37884	FlyBaseID:	FBgn0034997	Length:	764	Species:	Drosophila melanogaster

Alignment Length:	810	Identity:	148/810 - (18%)
Similarity:	239/810 - (29%)	Gaps:	305/810 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GGEGIEVDDQITKPLNLAN---------SAVLRAVEEEEQQAKCGDFPHKDFYPTERQSRPRQRG 92
            ||:|:.....:.|.|.|.|         ::|:..|.....:|..|...|:           .|.|
  Fly   151 GGDGLVYPPFVDKALKLLNLKQVAFEIENSVMSKVTCTACRAGAGMLQHQ-----------IQSG 204

  Fly    93 EVDALHHTLHQQLLNQIKTDYLSHQQDITIDRDTVLK-INRLATKR--HLLKRDHSWPPAEQDQP 154
            :.||       :|:..| |||.:   ::.|....|.: :.:|....  ::|||           .
  Fly   205 KTDA-------ELIRMI-TDYCT---NLNIQSARVCQGVAQLFGSELIYVLKR-----------V 247

  Fly   155 TINPEQSHQISCS------------PSHSIEALREKFQSPTLVIEPTANEVREQRRRDGGSKERS 207
            .::|::    .||            |.|..|           ||.|
  Fly   248 NLSPDE----LCSFVIGDGCADVYNPYHEWE-----------VIFP------------------- 278

  Fly   208 KTLQKHTKEPDLAEVFHQTPISKGFSAPETKAADVDLGLVAPRCEYYEQLAHKRSATPTLPTQIT 272
             .:.|..:.|||.......|..|                                   .|....|
  Fly   279 -PVPKPPRLPDLPIPMEAAPFFK-----------------------------------VLHISDT 307

  Fly   273 PYRPRYKRQAHS-LDRSRSRKRTVGAPELPPPKPRTSKPKVQRRCIKLATEVKISYGHDGDSEDD 336
            .|.|.|...::: .:.....:.:.|.|  ..|.....|....|:|......|.....|..::.
  Fly   308 HYDPHYAEGSNADCNEPLCCRLSSGRP--ATPNAAAGKWGDYRKCDTPKRTVDHMLSHIAETH-- 368

  Fly   337 PNSGQDVD--LETLPLPPTPVSPAAANLNQAKTAGRMVIDNVAVKQQQQM--------ALALATN 391
                :|:|  |.|..|||..|      .||.|.....:|.: .|||..:|        ||.   |
  Fly   369 ----KDIDYILWTGDLPPHDV------WNQTKEENLAIIKD-TVKQMVEMFPGVPIFPALG---N 419

  Fly   392 GSISPVNPSPSPLANTRIVPIRVEASADQLKLSAQQIYDDACSYLQDHQEMEDIQPRTESPTYVS 456
            ...:|||..|.|..|             |:.:|...:||:.           |||.|...|..|:
  Fly   420 HESAPVNSFPPPYVN-------------QVDISISWLYDEL-----------DIQWRRWLPQSVT 460

  Fly   457 AT------------GGIKLLQRQ-------------SSSTPSTPVPPPLPSPIMRSKSGQDSQAK 496
            .|            .|.:::...             :|:.|:|.:
  Fly   461 HTVRRGAFYSVLVRPGFRIISLNMNYCNNKNWWLLLNSTDPATEL-------------------- 505

  Fly   497 ENQTKRQGRIYSLETATEKQHEAHVEIAQLEAKYAHIQQSIAEHLLQIDAYMENAKQALQRSAQT 561
                  |..||.|::|.....:.||        ..||...   |...:..:..|..:.:.|...|
  Fly   506 ------QWFIYELQSAEFSNEKVHV--------IGHIPPG---HSDCLKVWSRNFYKIISRYEST 553

  Fly   562 TPVS--------------TPVPI-PPTATATPPPPPPPPPTALPARPISSA------------SN 599
            ....              .|..: .|...|...|...|.....|...|...            .:
  Fly   554 VTAQFYGHTHYDEFEMFYDPHDLNHPNGIAYIGPSVSPYYDLNPGYRIYYVDGDHDATTRLVIDH 618

  Fly   600 EAWDIFAHRQSPILAVESPLQAILRQIYT-RAAGLPKRLSKEIKEDADAEAEEESLTENVPIVER 663
            |:| |...:::.:..     ..|..::|| |||...|.|     ..:|.......||.|
  Fly   619 ESW-IMNLKEANLYG-----YPIWYKLYTARAAYNMKAL-----RPSDWNNLLNELTNN------ 666

  Fly   664 ALEDLHKIAVALEQKSEPAKLMHVELRTTPAV-SEAEHVVIKDEEQDADMEYRH-VSDVIANYEQ 726
              ::|.::......|:.||:         |.. :|.:..:|.|.......:.:| .::|.:..::
  Fly   667 --QELFELYYKYYWKNSPAR---------PTCDAECKKRLICDCRSGRSHDRKHFCAEVESKIDE 720

  Fly   727 LAKKEFEEWKEEQVVNS-----EEMLPKTE 751
            .:.|.::.|..:.:.||     ||..|.|:
  Fly   721 ESSKSWKSWFYKGLTNSAEDRTEEPAPTTD 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43897	NP_001261659.1	DUF4749	7..108	CDD:292558	17/79 (22%)
CG3376	NP_001246491.1	SapB	186..258	CDD:214797	21/108 (19%)
		Metallophos	299..563	CDD:278574	67/377 (18%)
		MPP_ASMase	301..600	CDD:277321	72/377 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3770
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900