DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43897 and SMPDL3A

DIOPT Version :9

Sequence 1:	NP_001261659.1	Gene:	CG43897 / 39153	FlyBaseID:	FBgn0264489	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_006705.1	Gene:	SMPDL3A / 10924	HGNCID:	17389	Length:	453	Species:	Homo sapiens

Alignment Length:	384	Identity:	80/384 - (20%)
Similarity:	137/384 - (35%)	Gaps:	93/384 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   985 RSSSPYGLNPVQTKAPPSPVNLPAKFTHVPQLEGHNIGLLVKTATEPLQQSMSASSTMLAATPPR 1049
            ||.....:.|...:.||..:   .:|.||..|.           .:|........:.:.|::...
Human    18 RSGLGLPVAPAGGRNPPPAI---GQFWHVTDLH-----------LDPTYHITDDHTKVCASSKGA 68

  Fly  1050 SAAQPTPFEFPSLEQAEEQHKFKSLASFDEVQRDFGVNRSF---DNVSPRPYLGIEGYKRVAWPP 1111
            :|:.|.||.....:...:    ..|::||.: ::.|...||   ...|| |::.:        |.
Human    69 NASNPGPFGDVLCDSPYQ----LILSAFDFI-KNSGQEASFMIWTGDSP-PHVPV--------PE 119

  Fly  1112 ASEERIIREFTPQPQT-QS--------PAPGAGGYYPQAHAPTAAAAAPPQQQYGAPSYDGQQPG 1167
            .|.:.:|...|....| ||        ||.|...|:||...|...:     :.|.|.: :..:|
Human   120 LSTDTVINVITNMTTTIQSLFPNLQVFPALGNHDYWPQDQLPVVTS-----KVYNAVA-NLWKP- 177

  Fly  1168 AQWQQQQQQQQVPQQQYQPQSQAQAP-----------YQPPQWNQPQQQQQQPSYQ----ASPYQ 1217
              |..::....:.:..:..|.....|           |..|  |.....:..|:.|    .|...
Human   178 --WLDEEAISTLRKGGFYSQKVTTNPNLRIISLNTNLYYGP--NIMTLNKTDPANQFEWLESTLN 238

  Fly  1218 QQQQQQPSYYPQQNGGSTYAQPPYNSYSQPQLPYSQDQTDLQQQQQQQQ----QQYPGAYAGQ-- 1276
            ..||.:...|       ..|..|..     .||.||:.|.:::...::.    |:|....|||
Human   239 NSQQNKEKVY-------IIAHVPVG-----YLPSSQNITAMREYYNEKLIDIFQKYSDVIAGQFY 291

  Fly  1277 -DSYRGASPGIITLRKEAPV-SQKPAPVYTSQPAAVSYQ---GGSKLRGDLKWPPPEYK 1330
             .::|. |..:::.:|.:|| |...||..|...:.:..|   .|.:|   .::.|.:||
Human   292 GHTHRD-SIMVLSDKKGSPVNSLFVAPAVTPVKSVLEKQTNNPGIRL---FQYDPRDYK 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43897	NP_001261659.1	DUF4749	7..108	CDD:292558
SMPDL3A	NP_006705.1	MPP_ASMase	40..336	CDD:277321	71/344 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3770
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900