DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LAMC1 and wb

DIOPT Version :9

Sequence 1:NP_002284.3 Gene:LAMC1 / 3915 HGNCID:6492 Length:1609 Species:Homo sapiens
Sequence 2:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster


Alignment Length:1598 Identity:424/1598 - (26%)
Similarity:628/1598 - (39%) Gaps:449/1598 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    52 PEFVNAAFNVTVVATNTCG-TPPEEYCVQTGVTGVTKSCHLCD------AGQPHLQ--------- 100
            |...|......:....||| ...||||.|.|    .|.|.:|:      |.|..:|         
  Fly   155 PPLFNVVPRAQISVNATCGQNGAEEYCKQVG----AKPCGICNAHSSDRAKQRSIQSLISSGSGS 215

Human   101 -HGAAFLTDYNNQADTTWWQSQTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTS-RPESFAIY 163
             .|:.|        :..||||.|:..|.|: ..:.:.|.|.:.|.|..|.||...| ||.|:.:.
  Fly   216 GSGSGF--------EEGWWQSPTLQGGRQF-EYVTILLDLKQTFQIFSVWLKSANSPRPASWILE 271

Human   164 KRTREDG----PWIPYQYY---SGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVA 221
            |..  ||    ||   ||:   ...|:..::.:.:.......::.:.:|:.:||...||..|.:.
  Fly   272 KSL--DGINFEPW---QYFGLSDADCQRRWNLSGQNGKYVFQNDTEIICSTQFSKPGPLENGVLH 331

Human   222 FSTLEGRPSAYNFDNSPVLQEWVTATDIRV-------TLNRLNTFGDEVFNDPKVLKSYYYAISD 279
            .|.|:.||.|  .|.||.|.:::|...||:       |.|:.|:. |.:.:.|.:.|..:|::|.
  Fly   332 ASLLKNRPGA--TDQSPELMKFITTRYIRIRLQGMHSTANQDNSL-DWLLDSPSLEKHSFYSLSQ 393

Human   280 FAVGGRCKCNGHASECMKNEFDKLV-CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCD 343
            ..|..|..|||||:...::..|.|: |.|:|||.|..||:|.|.|.|||:     :...||..|.
  Fly   394 LKVSARLDCNGHANRSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPY-----QMGGECEICQ 453

Human   344 CNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFR---LGNNEACSSCHCSPVGS 405
            |.|.::.|.:||.|.:     |.|.:|.:||.|..||.|...|:|   ....:.|..|.|:|..|
  Fly   454 CYGHAESCTYDPFLDK-----GICQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNPARS 513

Human   406 LSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDECNIETGRCVCKDNVE 470
            ........|.|:|..|..|..|:.|.||::.   ..|:.|.||..||:......:|.|.||.|||
  Fly   514 TGGCQSDGGSCNCLEGFQGKNCEECAPGYYG---DDCKRCECDERGSLGSTGSCSGVCQCKLNVE 575

Human   471 GFNCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGWRAE--QR-- 531
            |..|..|.||:|:|.:.|..|||.|:|.|.|..|     :|....:..|:...| |:..  ||  
  Fly   576 GSTCSECAPGYFDLSAENAEGCTSCWCSGVSQTC-----HSAKLQTLAFETLND-WKITDIQRVK 634

Human   532 ------DGSEASLEWSSERQDIAVISDSYFPRYFIAPAKFLGKQVLSYGQNLS--FSFRVDRRD- 587
                  |.....|.:::|..::..|       |:.|...:||.::.|||..|.  .|:.|.|.| 
  Fly   635 PISIPVDAETNRLIFANELDEVEAI-------YWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDR 692

Human   588 -----------------TRLSAEDLVLEGAGLRVSVPLIAQG--NSYPSETTVKYVFRLHEATDY 633
                             .:::..|..|:|.|:.::|.|...|  :..|:...:|...|..|..||
  Fly   693 SGKPTTGPNVILVGKNGLKIAFGDESLDGLGINLNVTLTEVGWYHVPPTVVDIKTRLRRTEGGDY 757

Human   634 PWRPALTPFEFQKLLNNLTSIKIRGTYS--------ERSAGYLDDVTLASARPGPGVPATWVESC 690
            ... ::|..:|..:|.:|.::.||..:.        ||:..|...|.|.      |..::.||.|
  Fly   758 HGE-SVTRSQFLSVLVSLDAVLIRAAFHTDQGETSLERAVIYSGGVELG------GKSSSQVEQC 815

Human   691 TCPVGYGGQFCEMCLSGYRRETPNLGPY---SPCVLCACNGHSETCDPETGVC-NCRDNTAGPHC 751
            .||.||.|..||.|..|::|...|...:   |.|:.|.|||||.:||.::|.| :|..||.|..|
  Fly   816 LCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRC 880

Human   752 EKCSDGYYGDSTAGTSSDCQPCPCP-------GGSSCAV-------------VPKTKEVVCTNCP 796
            |:|..||||:...||.:||:.|.||       ...||.:             :.:..|.:||.||
  Fly   881 ERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCP 945

Human   797 TGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYC 861
            .|.||..|::|||||||:|   ..|...|:.|.|       |.|.||..||||:.|..||.|::|
  Fly   946 EGYTGDHCQVCDDGYFGNP---RQPGSSCQRCDC-------AGGPCNVTTGECITCRGNTEGWHC 1000

Human   862 DRCKDGFFGNPLA------------------------------------------PNPADKCKAC 884
            :|||.|::|:|..                                          .|...:|.:|
  Fly  1001 ERCKLGYWGDPAVGCDPCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPSC 1065

Human   885 NCNLYGTMKQ------------------------------------------------------- 894
            ||:..|::.|                                                       
  Fly  1066 NCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEW 1130

Human   895 ----------------------------QSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQG 931
                                        .|.|:..||||.||.:|||:.|..|.||.:||.:|:|
  Fly  1131 ELVPDTEDPNSESTVACEECHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEG 1195

Human   932 CERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPE------------------ 978
            |..|.|...||...:|:..||||:|:.|:.||||..|....|||..|                  
  Fly  1196 CRDCRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPH 1260

Human   979 -----------------------------GCKPCDCHPEGSLSLQCK-DDGRCECREGFVGNRCD 1013
                                         ||:.|:|...||:..||. .||:|:||||:.|.:||
  Fly  1261 NGRCICPKFTRGLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCD 1325

Human  1014 QCEENYFYNRSWPGCQECPACYRLVKDKVADHRVKLQE-----LESLIANLGTGDEMVTDQAFED 1073
            .|...||   .:|.|:.| .|........||..:....     .:||:..|.....|.:......
  Fly  1326 TCAIGYF---GYPECRRC-GCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSA 1386

Human  1074 RLKE-----------AEREVMDL----LREAQDVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNT 1123
            :..|           .|.|..||    :|.|:     .:||..:..|.::..||....:..::  
  Fly  1387 QNPEGCTRCFCFGRSGECEQSDLSWGHIRMAE-----SRNLSVQQIRPHSVPSSDYEYIVVVQ-- 1444

Human  1124 IEETGNLAEQARAHVENTE--RLIEIASRELEKAKVAAANVSV-------------TQPESTGDP 1173
                   .|.:..|.|:.|  |:     .:|.....:..|||:             ..|:..||.
  Fly  1445 -------MEGSSFHREDAEIQRM-----NDLSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDR 1497

Human  1174 NN-------MTLLAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNLLLRTLAGENQTAFEIEE 1231
            .:       .||:.|.|.|..||:......:|::         .|::.||...       :|.||
  Fly  1498 TSSYGGFLYFTLITEGAHKPLERNILGQYPLVQL---------HAHSKLLLDF-------YEYEE 1546

Human  1232 LNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLSPLDSETLENEANNIK------ 1290
                :|.:.|::..:.     :||...:        |...:|  .:|..||.....||:      
  Fly  1547 ----FEYSLNVTHRVP-----LHESFWK--------YHHTSQ--AVDRNTLMAALQNIRHIFIRA 1592

Human  1291 MEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKG 1328
            ....:.::::.|.:  :.|....::|.    .||:.||
  Fly  1593 FAFADFQEVVLQNV--HMDAAIYIKGS----TNLIAKG 1624

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LAMC1NP_002284.3 Domain VI 34..285 72/264 (27%)
LamNT 44..284 CDD:214532 72/263 (27%)
EGF_Lam 285..330 CDD:238012 22/45 (49%)
Domain V 286..509 84/226 (37%)
Laminin_EGF 342..396 CDD:278482 18/56 (32%)
Laminin_EGF 398..445 CDD:278482 14/46 (30%)
Laminin_EGF 445..492 CDD:278482 20/46 (43%)
Domain IV 510..689 48/218 (22%)
LamB 553..678 CDD:214597 36/154 (23%)
Domain III 690..1030 154/536 (29%)
EGF_Lam 724..771 CDD:238012 24/47 (51%)
EGF_Lam 772..820 CDD:238012 22/67 (33%)
Laminin_EGF 828..875 CDD:278482 21/88 (24%)
EGF_Lam 883..933 CDD:238012 24/132 (18%)
EGF_Lam 935..980 CDD:214543 20/91 (22%)
EGF_Lam 982..1029 CDD:238012 20/47 (43%)
Domain I/II 1031..1609 64/346 (18%)
t_SNARE 1072..1155 CDD:197699 18/99 (18%)
MA 1091..1302 CDD:214599 42/238 (18%)
MCP_signal 1123..1255 CDD:304920 28/153 (18%)
V_Alix_like 1180..>1336 CDD:187408 30/155 (19%)
Laminin_I 1287..1530 CDD:283627 9/48 (19%)
SH3BP5 1361..1592 CDD:283045
wbNP_723870.1 Laminin_N 164..396 CDD:278484 69/252 (27%)
EGF_Lam 401..450 CDD:238012 22/53 (42%)
TNFRSF <407..507 CDD:304602 37/109 (34%)
EGF_Lam 505..552 CDD:238012 15/49 (31%)
Laminin_EGF 550..597 CDD:278482 20/46 (43%)
Laminin_B 660..798 CDD:278481 33/138 (24%)
EGF_Lam 851..900 CDD:238012 24/48 (50%)
Laminin_EGF <943..971 CDD:278482 15/30 (50%)
VSP 953..1414 CDD:146106 115/474 (24%)
Laminin_EGF 974..1018 CDD:278482 21/50 (42%)
EGF_Lam 1017..1065 CDD:238012 2/47 (4%)
Laminin_EGF 1065..>1105 CDD:278482 5/39 (13%)
EGF_Lam 1150..1197 CDD:238012 19/46 (41%)
Laminin_EGF 1199..1247 CDD:278482 20/47 (43%)
EGF_Lam 1247..1292 CDD:238012 1/44 (2%)
Laminin_EGF 1294..1342 CDD:278482 22/51 (43%)
Laminin_EGF 1340..1392 CDD:278482 9/52 (17%)
Laminin_B 1486..1611 CDD:278481 30/161 (19%)
EGF_Lam 1669..1716 CDD:238012
Laminin_EGF 1718..1767 CDD:278482
EGF_Lam 1772..1819 CDD:238012
CrfC <1933..2267 CDD:223771
Laminin_II 2277..2400 CDD:283628
LamG 2399..>2492 CDD:304605
Laminin_G_2 2616..2755 CDD:280389
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.