DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and Pard3

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_006531583.1	Gene:	Pard3 / 93742	MGIID:	2135608	Length:	1337	Species:	Mus musculus

Alignment Length:	926	Identity:	164/926 - (17%)
Similarity:	287/926 - (30%)	Gaps:	304/926 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DNVPWGFRLV-----GGADYDYPLTVVKVTEGSIADEAGLRVE-DIIVRINDTAATPLTHDEAHR 69
            |..|.|..:|     ||....  |.|.::.:|..|::..|..| |.||||||........::|..
Mouse   280 DGGPLGIHVVPFSARGGRTLG--LLVKRLEKGGKAEQENLFHENDCIVRINDGDLRNRRFEQAQH 342

  Fly    70 LIMGS--GSVFYFGVYRENEEDAYECLK----------KFPTSEGSLTKSPMPTISPSP---TPS 119
            :...:  ..|.:|.|.....::.||.|.          :|......:....:...:|..   .|.
Mouse   343 MFRQAMRARVIWFHVVPAANKEQYEQLSQREKNNYSPGRFSPDSHCVANRSVANNAPQALPRAPR 407

  Fly   120 LSQLTETTNARTPEPEPFVPLPRELAAATMAAPAV-EVDVDVLAECRQPMSEVHSEEKRG----- 178
            |||..|..:|....|.......:..||..:|.|:| ..:|..:...::....::.:.|:|
Mouse   408 LSQPPEQLDAHPRLPHSAHASTKPPAAPALAPPSVLSTNVGSVYNTKKVGKRLNIQLKKGTEGLG 472

  Fly   179 ----------------------------------------DVNGHDAPGQADEGGLPV------- 196
                                                    :|||.|..|::.|..:.:
Mouse   473 FSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLAGKSQEEVVSLLRSTKME 537

  Fly   197 ----------ENLYLPDLPDRPCSALSERQEIKLVEEEIAAVLSGESEVL--------------- 236
                      |..:.|...:...|.:...:|.|..:|::.....|..|.|
Mouse   538 GTVSLLVFRQEEAFHPREMNAEPSQMQTPKETKAEDEDVVLTPDGTREFLTFEVPLNDSGSAGLG 602

  Fly   237 ---------KEHNVLGVNFYRIFPKP---GVCMSSDVLRSLNEEVTKTKLEK--DKENRQWSTFL 287
                     :.|..||     ||.|.   |...|.|....:|:::.....|.  .|.|::....|
Mouse   603 VSVKGNRSKENHADLG-----IFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKANQEAMETL 662

  Fly   288 QRPNRPVPKSKQSLEAERRAANAYKVTIVKSAPREKSPMPEAKPAPKEATPPKEVEKKE------ 346
            :|          |:..|.......::.:.:...|.........||..|.....|::.:|
Mouse   663 RR----------SMSTEGNKRGMIQLIVARRISRCNELRSPGSPAAPELPIETELDDRERRISHS 717

  Fly   347 ---------EEP--------VPEEVVEPEPEPEKDEEPLPTDSEVPNLEQLPETELPDEQPEKSD 394
                     |.|        :..|..:.:..|..:   :|.|..|    .:.:..||...|..||
Mouse   718 LYSGIEGLDESPTRNAALSRIMGESGKCQLSPTVN---MPHDDTV----MIEDDRLPVLPPHLSD 775

  Fly   395 APKEVCEPEV-VIQTEPGSPDGNEASD-GPAGATPPAEPI----------TPVPVKSEEELALER 447
            ........:| .|.||.|:......|| .....:|..:|:          ..:..|..::.:...
Mouse   776 QSSSSSHDDVGFIMTEAGTWAKATISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDAS 840

  Fly   448 QLADVQRQLAALSSLPSTIQSTLDAVTKQLA-----DLLPTIKLQQQEK---------------- 491
            ||..|:.:.:....|....::.|:.|..|.|     |:.|::.|::...
Mouse   841 QLDFVKTRKSKSMDLGIADETKLNTVDDQRAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGN 905

  Fly   492 ----------------------------QLPQIDENSGNEEQVEEGVTTATNTINTAGETEDAGK 528
                                        ..|.:|::....|.:||...          |:..:|:
Mouse   906 IPFHRPRPRIIRGRGCNESFRAAIDKSYDKPMVDDDDEGMETLEEDTE----------ESSRSGR 960

  Fly   529 DISISGSDNPPVGPCESNEDRCDANDREVAEISRSTDDNRLAKDKKKDLDQEQKQQQQQQ--QEP 591
            :...:.||.|..    |.|.:.:.:..:..:..|..|  :..||||||.::|:.:.:.::  .:.
Mouse   961 ESVSTSSDQPSY----SLERQMNGDPEKRDKTERKKD--KAGKDKKKDREKEKDKLKAKKGMLKG 1019

  Fly   592 LSEEQNFKKQKRHDVIEEL-----------EEHLVR----------KNNPRRSKRAFGPLVPSSE 635
            |.:...|.|.::.|.:|::           ||..||          |....|.::|       .|
Mouse  1020 LGDMFRFGKHRKDDKMEKMGRIKIQDSFTSEEDRVRMKEEQERIQAKTREFRERQA-------RE 1077

  Fly   636 RPL---------------VLPGGRRWY--------RPKDAYNDEFIAETLSAQAELITGSTLGVN 677
            |..               :|.||...|        ||:.. .:..:.:||.||
Mouse  1078 RDYAEIQDFHRTFGCDDELLYGGMSSYEGCLALNARPQSP-REGHLMDTLYAQ------------ 1129

  Fly   678 FMKYQKPERKIDLNRS 693
             :|..:..:..|.|||
Mouse  1130 -VKKPRSSKPGDSNRS 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	20/71 (28%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558	9/41 (22%)
Pard3	XP_006531583.1	DUF3534	2..83	CDD:338230
		PDZ_signaling	272..347	CDD:238492	20/68 (29%)
		PDZ_signaling	465..544	CDD:238492	8/78 (10%)
		PDZ_signaling	588..681	CDD:238492	17/107 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900