DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and PDLIM7

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_005442.2	Gene:	PDLIM7 / 9260	HGNCID:	22958	Length:	457	Species:	Homo sapiens

Alignment Length:	428	Identity:	95/428 - (22%)
Similarity:	136/428 - (31%)	Gaps:	165/428 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PWGFRLVGGADYDYPLTVVKVTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSGSVF 78
            ||||||.||.|::.||::.::|.|..|.:||:.|.|.::.|:...|..|||.||...|...|...
Human    13 PWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLTHIEAQNKIRACGERL 77

  Fly    79 YFGVYRENEEDAYECLKKFPTSEGSLTKSPMPTISPSPTPSLSQLTETTNARTPEPEPFVPLPRE 143
            ..|:.|                             ..|..|..|     .|..|..:|    ||
Human    78 SLGLSR-----------------------------AQPVQSKPQ-----KASAPAADP----PR- 103

  Fly   144 LAAATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGDVNGHDAPGQAD----EGGLPVENLYLPDL 204
                ...||:|.     |.:..:|..               ||..||    :.|.|:.    |.:
Human   104 ----YTFAPSVS-----LNKTARPFG---------------APPPADSAPQQNGQPLR----PLV 140

  Fly   205 PDRPCSALSERQEIKLVEEEIAAVLSGESEVLKEHNVLGVNFYRIFPKPGVCMSSD--VLRSLNE 267
            ||.....|.|..|                            .:|  |:||...|..  :|..|..
Human   141 PDASKQRLMENTE----------------------------DWR--PRPGTGQSRSFRILAHLTG 175

  Fly   268 EVTKTKLEKDKENRQWSTFLQRPNRPVPKSKQSLEAERRAANAYKVTIVKSAPREKSPMPEAKPA 332
              |:...:.|:|:.:.|:.:.|...|.|.|                    |.|:|..|.|.| |:
Human   176 --TEFMQDPDEEHLKKSSQVPRTEAPAPAS--------------------STPQEPWPGPTA-PS 217

  Fly   333 PKEATPPKEVEKKEEEPVPEEVVEPEPEPEKDEEPLPTDSEVPNLEQLPETELPDEQPEKSDAPK 397
            | .:.||..|:....|         ...|:|....|...|:       |.|..|.:....
Human   218 P-TSRPPWAVDPAFAE---------RYAPDKTSTVLTRHSQ-------PATPTPLQSRTS----- 260

  Fly   398 EVCEPEVVIQTEPGSPDGNEASDGPAGATPPAEPITPV 435
                   ::|...|...|..:::|.          |||
Human   261 -------IVQAAAGGVPGGGSNNGK----------TPV 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	26/60 (43%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
PDLIM7	NP_005442.2	PDZ_signaling	5..79	CDD:238492	27/65 (42%)
		Atrophin-1	<81..254	CDD:331285	59/309 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..142		21/126 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..226		18/71 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..258		5/25 (20%)
		LIM1_Enigma	282..333	CDD:188836	95/428 (22%)
		LIM2_Enigma	341..392	CDD:188840
		LIM3_Enigma	400..454	CDD:188842
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100