DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zasp67 and DLG5

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_004738.3	Gene:	DLG5 / 9231	HGNCID:	2904	Length:	1919	Species:	Homo sapiens

Alignment Length:	914	Identity:	160/914 - (17%)
Similarity:	272/914 - (29%)	Gaps:	344/914 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GFRLVGGADY-----DYPLTVVKVTEGSIADEAGLRVEDIIVRINDT------------------ 57
            ||.:..|.:.     |..:.|.||.:||||| ..|||.|.::||||.
Human   636 GFDMAEGVNEPCFPGDCGIFVTKVDKGSIAD-GRLRVNDWLLRINDVDLINKDKKQAIKALLNGE 699

  Fly    58 ----------------AATPLTHDEAHRLIMG---SGSVFYFGVYRE------------------ 85
                            ..|||     |..:.|   ||.....|||..
Human   700 GAINMVVRRRKSLGGKVVTPL-----HINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGD 759

  Fly    86 ----------NEEDAYECLKKFPTSEGSLTKSPMPTISPSPTPSLSQLTETTNARTPEPEPFVPL 140
                      :.:...||.....:.:.|||.|.:.....|.:.|...:.|...
Human   760 RIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVFPQSSSWSGQNIFENIK------------ 812

  Fly   141 PRELAAATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGDVNGHDAPGQAD-----------EGGL 194
                            |.|.:...|....||.:..||..:. |:...|.|           |.|.
Human   813 ----------------DSDKMLSFRAHGPEVQAHNKRNLIQ-HNNSTQTDIFYTDRLEDRKEPGP 860

  Fly   195 PVEN---LYLPDLPDRP-------CSALSE-----------------------RQEIKLVEEEIA 226
            |..:   |:.| .|..|       |.:.||                       |:.:...|.|:.
Human   861 PGGSSSFLHKP-FPGGPLQVCPQACPSASERSLSSFRSDASGDRGFGLVDVRGRRPLLPFETEVG 924

  Fly   227 AVLSGESEVLKEHNVLGVNFYRIFPKPGVCMSSDVLRSLNEEVTKTKLEKDKENRQWSTFLQRPN 291
            ....||:.:.|..:. |.|....:||  ..:||   .::.|:::..|..|.:::.......:||.
Human   925 PCGVGEASLDKADSE-GSNSGGTWPK--AMLSS---TAVPEKLSVYKKPKQRKSIFDPNTFKRPQ 983

  Fly   292 RP-----------------------------VPKSKQSLEAERR--AANAYKVTIVKSAPREKSP 325
            .|                             .|:...|::.:.|  .::..:.|:|.|:|....|
Human   984 TPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSIKFQHRLETSSESEATLVGSSPSTSPP 1048

  Fly   326 M---PEAKPA-PKEATPPKEVE--------------------KK--EEEPVPEEVVE-------P 357
            .   |:..|. |..|:||::..                    ||  :|:...::|.|       |
Human  1049 SALPPDVDPGEPMHASPPRKARVRIASSYYPEGDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRP 1113

  Fly   358 EPEPE---------------KDEEPLPTDSEV-PNLEQ-LPETELPDEQPEKSDAPKEVCEPEVV 405
            :..|.               ::::.:|...|: |.|:: .|.:  |......|:.|.....|.|.
Human  1114 KSAPSFRPKLAPVVIPAQFLEEQKCVPASGELSPELQEWAPYS--PGHSSRHSNPPLYPSRPSVG 1176

  Fly   406 IQTEPGSPDGNEAS-------------DGPAGATPPAEPITP----VPVKSEEELALE---RQLA 450
            ......:|....:|             .||..:.|.|....|    ..|:.:..|:|:   |..:
Human  1177 TVPRSLTPSTTVSSILRNPIYTVRSHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCS 1241

  Fly   451 DVQRQLA--ALSSLPSTIQSTLDAVTKQLADLLPTIKLQQQEKQLPQIDENSGNEEQVEEGVTTA 513
            |.....|  ..:||||:.:....:          .::.:.:..::|.......:....|.|
Human  1242 DYSEMRATHGSNSLPSSARLGSSS----------NLQFKAERIKIPSTPRYPRSVVGSERG---- 1292

  Fly   514 TNTINTAGETEDAGKDISISGSDNPPVGPCESNE-DRCDANDREVAEISRSTDDNRLAKDKKKDL 577
                           .:|.|....||..|...:. ..|..:....:.:.|...:.....:::||
Human  1293 ---------------SVSHSECSTPPQSPLNIDTLSSCSQSQTSASTLPRIAVNPASLGERRKD- 1341

  Fly   578 DQEQKQQQQQQQEPLSEEQNFKKQKRHDVIEELEEHLVRKNNPRRSKRAFGPLVPSSERPLVLPG 642
                        .|..||      .||..:::..|.|             |..:.|.|:     |
Human  1342 ------------RPYVEE------PRHVKVQKGSEPL-------------GISIVSGEK-----G 1370

  Fly   643 GRRWYRPKDAYNDEFIAETLSAQAELITGSTL----GVNFMKYQKPERKIDLNRS----EVYKYL 699
            |        .|..:....:::.||.|..|..|    |:|.....:.:.::.:.:.    .:....
Human  1371 G--------IYVSKVTVGSIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQY 1427

  Fly   700 NPHL 703
            |||:
Human  1428 NPHV 1431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	25/100 (25%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558	8/53 (15%)
DLG5	NP_004738.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..142
		Takusan	130..212	CDD:282652
		TPR_MLP1_2	231..353	CDD:285204
		COG1340	295..587	CDD:224259
		FliJ	310..449	CDD:304890
		BAR	417..601	CDD:299863
		PDZ_signaling	620..707	CDD:238492	20/71 (28%)
		DegQ	<702..771	CDD:223343	10/73 (14%)
		PDZ_signaling	722..790	CDD:238492	10/67 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	927..1122		36/200 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1150..1187		7/38 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1201..1230		6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1245..1264		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1306		7/53 (13%)
		PDZ	1347..1429	CDD:214570	18/113 (16%)
		dbPDZ_assoc	1427..1499	CDD:293216	3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1434..1493
		PDZ	1499..1582	CDD:214570
		SH3_DLG5	1597..1659	CDD:212794
		GuKc	1732..1908	CDD:214504
		Guanylate_kin	1740..1907	CDD:279019
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900