DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zasp67 and PDLIM1

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_066272.1	Gene:	PDLIM1 / 9124	HGNCID:	2067	Length:	329	Species:	Homo sapiens

Alignment Length:	276	Identity:	75/276 - (27%)
Similarity:	115/276 - (41%)	Gaps:	52/276 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PWGFRLVGGADYDYPLTVVKVTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSGSVF 78
            |||||||||.|::.||.:.:||.||.|..|.|.:.|:|..|:....:.:||.||...|.|.....
Human    13 PWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLEAQNRIKGCTDNL 77

  Fly    79 YFGVYRENEEDAYECL-----KKFP-----TSE-------GSL-TKSPMP-TISPSPTPSLSQLT 124
            ...|.| :|...:..|     |:.|     .||       ||. .:|.|| |.||:.:.:...:|
Human    78 TLTVAR-SEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAHNRSAMPFTASPASSTTARVIT 141

  Fly   125 ETTN--ARTPEPEPFVPLPRELAAATMAAPAVEVDVDVLAECRQPMSEVHSEE--------KRGD 179
            ...|  |.....|........|.:.| ||..||.:...|...:.|.|.|..:|        ::.:
Human   142 NQYNNPAGLYSSENISNFNNALESKT-AASGVEANSRPLDHAQPPSSLVIDKESEVYKMLQEKQE 205

  Fly   180 VNGHDAPGQADEGGLPVENLYLPDL--------PDRPCSALSERQEIKLVEEEIAAVLSGESEVL 236
            :|  :.|.|:      ...|.|.::        |::|    |..:.:|....::||.: |.::.|
Human   206 LN--EPPKQS------TSFLVLQEILESEEKGDPNKP----SGFRSVKAPVTKVAASI-GNAQKL 257

  Fly   237 KEHNVLGVNFYRIFPK 252
            ...:..|.....:|.|
Human   258 PMCDKCGTGIVGVFVK 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	28/60 (47%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
PDLIM1	NP_066272.1	PDZ_signaling	10..82	CDD:238492	28/68 (41%)
		DUF4749	138..230	CDD:318205	20/100 (20%)
		LIM_CLP36	260..311	CDD:188832	3/14 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10447
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.100