DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zasp67 and Dlg5

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_017171686.1	Gene:	Dlg5 / 71228	MGIID:	1918478	Length:	1931	Species:	Mus musculus

Alignment Length:	905	Identity:	169/905 - (18%)
Similarity:	271/905 - (29%)	Gaps:	321/905 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GFRLVGGADY-----DYPLTVVKVTEGSIADEAGLRVEDIIVRINDT------------------ 57
            ||.:..|.:.     |..:.|.||.:||||| ..|||.|.::||||.
Mouse   641 GFDMAEGVNEPCFPGDCGIFVTKVDKGSIAD-GRLRVNDWLLRINDVDLINKDKKQAIKALLNGE 704

  Fly    58 ----------------AATPLTHDEAHRLIMG--------SGSVFYFGVYRE------------- 85
                            ..|||     |..:.|        ||.....|||..
Mouse   705 GAINMVVRRRKSLGGKVVTPL-----HINLSGQKGSRPQDSGISLENGVYAAAVVPGSPAAKEGS 764

  Fly    86 ---------------NEEDAYECLKKFPTSEGSLTKSPMPTISPSPTPSLSQLTETTNARTPEPE 135
                           :.:...||.....:.:.|||.|.:.....|.:.|...:.|...
Mouse   765 LAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVFPQSSSWSGQNIFENIK------- 822

  Fly   136 PFVPLPRELAAATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGDVNGHDAPGQAD---------- 190
                                 |.|.:..||....||.:..|| ::..|:...|.|
Mouse   823 ---------------------DSDRMLSCRAHGPEVQAHNKR-NLLQHNNSTQTDIFYTDRLEDR 865

  Fly   191 -----EGG------LPVENLYLPDLPDRPCSALSERQEIKLVEEEIAA--------------VLS 230
                 .||      .|......|..| :.|.:.||| .:.....:.:|              :||
Mouse   866 KELGHSGGSSSFLHKPFSGSSSPVSP-QACPSTSER-SLNSFRSDTSAERGYGLVDMRSQRPLLS 928

  Fly   231 GESEV---------LKEHNVLGVNFYRIFPKPGVCMSSDVLRSLNEEVTKTKLEKDKENRQW--- 283
            .|:||         |.:.:..|.|....:||.       ||.|.:.....:..:|.|:.:..
Mouse   929 FETEVGPCGAVEVPLDKIDPEGSNSGGTWPKA-------VLGSTSGPEKLSVYKKPKQRKSIFDP 986

  Fly   284 STFLQRPNRP-----------------------------VPKSKQSLEAERR--AANAYKVTIVK 317
            :|| :||..|                             .|:...|::.:.|  .::..:.|:|.
Mouse   987 NTF-KRPQTPPKIDYLLPGPGLTHSPQPSKRVGSLTPPKPPRRSDSIKFQHRLETSSESEATLVG 1050

  Fly   318 SAPR---EKSPMPEAKPA-PKEATPPKEVEKKEEEPVPEEVVEPEPEPEKDEEPLPTDSEVPNLE 378
            |:|.   ..:|.|...|: |..|:||::...:.....       ..|.:.|...||  ::.|..|
Mouse  1051 SSPSTSPPSAPPPSMDPSEPTHASPPRKARVRIASSY-------HSEGDGDTSYLP--AKKPCDE 1106

  Fly   379 QLPETELPDEQPEKSDAPKEV---------------C--EPEVVIQTEPGSPDGNEASD-GPAGA 425
            .|...:: ||..:|...||..               |  |.|.|......||:|.|.|. .|..|
Mouse  1107 DLTSQKV-DELGQKRRRPKSAPSFRPKISPVVIPAQCLEEQECVPAIGELSPEGQEWSPYSPGHA 1170

  Fly   426 TPPAEPI---------------TP------------VPVKSEEELALERQLADVQRQLAALSSLP 463
            :....|:               ||            ..|:|...|....  ..|.|...:.|..|
Mouse  1171 SRHGNPLLYPNRPSVGTVPRSMTPGTTVGSILRNPIYTVRSHRVLPCGS--PPVPRDAGSQSLSP 1233

  Fly   464 STIQS---TLDAVTKQLADLLPTIKLQQQEKQLP---QIDENSGNEEQVEEGVTTATNTINTAGE 522
            |....   :||...:..:| ...::..|....||   ::..:|..:.:.|......|.....:..
Mouse  1234 SVQHQGRLSLDLSHRACSD-YSEMRASQGSNSLPSSARLGSSSNLQFKAERIKIPLTPRYPRSVM 1297

  Fly   523 TEDAGKDISISGSDNPPVGPCESNE-DRCDANDREVAEISRSTDDNRLAKDKKKDLDQEQKQQQQ 586
            ..|.| .:|.|....||..|...:. ..|.......:.:.|...:.....:::||
Mouse  1298 GSDRG-SLSHSECSTPPRSPLNIDTLSSCSQPQTTASTLPRIAVNPSSHGERRKD---------- 1351

  Fly   587 QQQEPLSEEQNFKKQKRHDVIEELEEHLVRKNNPRRSKRAFGPLVPSSERPLVLPGGRRWYRPKD 651
                     :.|.::.||..:::..|.|             |..:.|.|:     ||
Mouse  1352 ---------RPFVEEPRHVKVQKGSEPL-------------GISIVSGEK-----GG-------- 1381

  Fly   652 AYNDEFIAETLSAQAELITGSTL----GVNFMKYQKPERKIDLNRS----EVYKYLNPHL 703
            .|..:....:::.||.|..|..|    |:|.....:.:.::.:.:.    .:....|||:
Mouse  1382 VYVSKVTLGSIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHI 1441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	25/105 (24%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558	8/53 (15%)
Dlg5	XP_017171686.1	Takusan	129..213	CDD:368141
		Smc	<141..564	CDD:224117
		PDZ_signaling	625..712	CDD:238492	20/71 (28%)
		PDZ_signaling	<741..800	CDD:238492	8/58 (14%)
		PDZ	1357..1439	CDD:214570	17/107 (16%)
		dbPDZ_assoc	1437..1512	CDD:374667	3/5 (60%)
		PDZ	1513..1594	CDD:214570
		SH3_DLG5	1610..1672	CDD:212794
		GuKc	1744..1920	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900