DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and Pdzph1

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_081277.1	Gene:	Pdzph1 / 69239	MGIID:	1916489	Length:	1238	Species:	Mus musculus

Alignment Length:	795	Identity:	155/795 - (19%)
Similarity:	245/795 - (30%)	Gaps:	255/795 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DYPLT--VVKVTEGSIADEA-----GLRVEDIIVRINDTAATPLT-------------------- 63
            |:|.|  |:|..:|....|.     .:.||........|.|..||
Mouse   120 DFPNTVEVLKPAKGKFIREVKCGAFNVHVETTKSIFCKTGAQNLTKRRCPTCHQHYSVQQVWRGS 184

  Fly    64 ----HDEAHRLIMGS------GSVFYFGVYRE----------NEEDAYECLKK---------FPT 99
                |...||.::..      .|.:..||.|.          .:|...|.:.|         .|.
Mouse   185 KSRGHFSKHRTVLAEEFKRRVPSTYRRGVSRSEVPSVNISIVGKEIMVEYISKKQNTFINICHPN 249

  Fly   100 SEGSLTK---SPMPTISPSPTPSLSQ--LTETTNARTPEPEPFVPLPRELAAATMAAPAVEVDVD 159
            |.|.|||   .|:...:..|..|.||  :....|.|............:...:..|......|..
Mouse   250 SIGKLTKHRRGPLKHTTDEPCESASQPGINHPENQRLENQHQSSDAFHDAPCSVNAVQKENSDTI 314

  Fly   160 VLAECRQPMSEVHSEEKRGDVNGHDAPGQADEGGLPVENLYLPDLPDRPCSALSERQEIKLVEEE 224
            |::....|..|   :||...:  ..||..::||.                ||.|.::.:::.::
Mouse   315 VVSLSSPPRRE---KEKPNTL--PSAPDDSEEGE----------------SATSPQKVLQITQD- 357

  Fly   225 IAAVLSGESEVLKEHNVLGVNFYRIFPKPGVCM--SSDVLR--SLNE-EVTKTKLEK----DKEN 280
                     :.|::|.....:          |:  ||:.||  |||. :::|..||.    |:|.
Mouse   358 ---------KPLEQHCFTADS----------CLPTSSETLRTTSLNNVDLSKMSLEDSRDVDEER 403

  Fly   281 RQWSTFLQR--PNRPVPKSKQSLEAERRAANAYKVTIVKSAPREKSPM-----------PEAKPA 332
            :..|...:.  |:..|............|.|:. :.|..::..|.||:           .:....
Mouse   404 KNSSDVRENITPDSQVQPCTAGTNGPLSAVNSI-IPIQDASGSEFSPLSFLTLQLLGAKADNMGC 467

  Fly   333 PKEATPPKEVEKKEEE---PVPEEVVEPEP------EPEKDEEPLPTDSEVPNLEQLPETELPDE 388
            ..|.|.|.|..:....   ||.|:..:|.|      ...:..||:.|.....:..|....|...|
Mouse   468 RGEETLPGEGHESSNSLLFPVSEQAAKPSPLLSPSHRVSRCSEPVETTGNTFSFSQYIGVEREQE 532

  Fly   389 --------------------QPEKSDAPKEVCEPEVVIQT----EPGSP---------DGNEASD 420
                                ||.:...|:   .|.|.|.:    .|.||         :.|:..|
Mouse   533 KVHYRLINKASLHNDSSSNIQPLERKDPQ---SPAVTIASCSILVPKSPLHGNIHSSVEWNQTED 594

  Fly   421 GPAGATPPAEPITPVPVKSEEELALERQLADVQ-RQLAALSSLPSTIQ------STLDAVTKQLA 478
            ....|.........|||.:.....||:.||... ::....|:.|..|:      |.|:.|....:
Mouse   595 HANHAERAGLSRMEVPVMASITNELEQSLATQNYKESTVDSNSPMAIRNPRESTSYLENVGDDAS 659

  Fly   479 DLLPTIK-----------LQQQEKQLPQIDENSGNEEQVEEGVTT-----ATNTINTAGETEDAG 527
            ..||.:|           .:.|.:...|:|....:.|....|.||     ...|: .:.:..::.
Mouse   660 QALPVVKNMCHRNFEDLTRENQNEICSQMDFLQNSSESTSVGHTTEKLFLIDKTL-ASDDDSNSN 723

  Fly   528 KDISISGSDNPPVGP--CESNEDR--CD--ANDREVAEISRSTDDNRLAKDKKKDLDQEQKQQQQ 586
            :|....|.:|....|  |:....|  |:  .|.|...|:|....|..|:..|:|.|
Mouse   724 RDHKTCGLNNFQQEPAECQRTTSRVYCEESGNQRYPTEVSCHPVDILLSPQKQKAL--------- 779

  Fly   587 QQQEPLSEEQNFKKQKRHDVIEELEEHLVRKNNPRRSKRAFGPLVPSSERPLVLPGGR------- 644
                   ::||                 :..||||:           ..:.|.|.|||
Mouse   780 -------KDQN-----------------LEINNPRK-----------LSQELALRGGRASDGSQE 809

  Fly   645 ----RWYRPKDAYND 655
                :|.|.:..:.|
Mouse   810 EAIEQWARRRQQFKD 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	16/85 (19%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558	1/3 (33%)
Pdzph1	NP_081277.1	PDZ_signaling	903..981	CDD:238492
		PH-like	986..1093	CDD:302622
		PH	993..1094	CDD:278594
		PH-like	1123..1215	CDD:302622
		PH	1125..1216	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900