DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zasp67 and Pdzd2

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001074533.1	Gene:	Pdzd2 / 68070	MGIID:	1922394	Length:	2796	Species:	Mus musculus

Alignment Length:	694	Identity:	133/694 - (19%)
Similarity:	218/694 - (31%)	Gaps:	205/694 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GADYDYPLTVVKVTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSGSVFYFGVYREN 86
            |.....|.::....|.|.:|...| |||......:....|.:|:.:.:    .||       .|:
Mouse  1498 GVSEPSPSSMYGDAEDSSSDPESL-VEDPRAAARNNWPAPPSHESSRK----EGS-------SES 1550

  Fly    87 EEDAYE-CLKKFPTSEGSLTKSPMPTISPS-----PTPSLSQ---------------LTETTNAR 130
            |::..| |      :.|...::|:|..:|:     ..||:.|               :|..:|..
Mouse  1551 EDEQIEIC------APGGCPETPVPAQAPAQAAGGAVPSVQQTVREPVGDACEKACFMTGASNTC 1609

  Fly   131 TP-EPEPFVPLP-RELAAATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGDVNGHDAPGQADEG- 192
            .| ..:||..|. ..|...|.|  .|:.....:..|.:....|.|   .|.|.|...|.|....
Mouse  1610 IPGSSQPFSFLDVSSLEHETWA--GVQTSRSHMPGCAEETLAVSS---TGSVVGDSQPSQTTRPC 1669

  Fly   193 GLPVENLYLPDL-------------PDRPCSALSERQEIKLVEEEIAAVLSGESEVLKEHNVLGV 244
            |.|...|..||:             ||:...|......:..:..|  ...:||:.:...|...|.
Mouse  1670 GNPPFVLRNPDMVNGLGQDLLDEGTPDKGADASHVMSSVYALGAE--GPKNGEAVLANLHIAKGG 1732

  Fly   245 NFYRIFPKPGVCMSSDVL---RSLNEEVTKTKLEKDKENRQWSTFLQRPNRPVPKSKQSLEAERR 306
            |...:..||.......::   :.:|::.....|:...|..|.|.....|..
Mouse  1733 NLDGLLQKPKTTSRRPIMTWFKDINKDSQGAHLQSKSEKEQPSMLAMSPGS-------------- 1783

  Fly   307 AANAYKVTIVKSAPREKSPMPEAKPAPKEATPPKEVEKKEEEPVPEEVVEPEPEPEKDEEPLPTD 371
                 |...|..:.|:...:|       ::.||::..::.::..|:..||.....:|     |..
Mouse  1784 -----KGNTVNPSHRKGMAVP-------KSPPPRQKSQENKDLSPKSPVETLSNCQK-----PKG 1831

  Fly   372 SEVPNLEQL-----PETELPDEQPEK---SDAPKEVCEPE---------------VVIQTEPGSP 413
            |  |.|::|     ...|.|...|.|   :|..|.:..|:               :..|.||.:.
Mouse  1832 S--PKLKRLNSKSKASPEAPVASPAKGGRTDHRKSLPSPQAAHKMLSKAVSHRLHIADQEEPKNT 1894

  Fly   414 DGNEASDGPAGATPPAEPITPVPVKSEEELALERQLADVQRQLAALSSLPSTIQST-LDAVTKQL 477
            .|:.:.  |....|.::|                       .|||..||.::...| :..:|..|
Mouse  1895 AGDTSK--PPQCVPESKP-----------------------PLAASGSLRTSASDTSIRTITSPL 1934

  Fly   478 ADLLPTIKLQQQEKQLPQIDENSGNEEQVEEGVTTATNTINTAGETEDAGKDISISGSDNPP--- 539
            .          ..|.||            |:|   |.|..:.|...|   .|.|...:..||
Mouse  1935 T----------SPKPLP------------EQG---ANNRFHMAVYLE---SDTSCPATSRPPRYG 1971

  Fly   540 ------------VGPCESNEDRCDANDREVAEISRSTDDNRLAKDKKKDLDQEQKQQQQQQQEPL 592
                        |.|..|..:...|..|:..:.:.|..|..|. :..:.....:|..::...:||
Mouse  1972 PEGKVPHANSGSVSPSASRTNIALAGVRQSKQFTHSRVDLVLT-EAAQPQGISEKGTEKMASDPL 2035

  Fly   593 SEEQNFKKQKRHDVIEELEEHLVRKNNPRRSKRAFGPLVPSSER 636
            ......|              ::..::.|..|.|.|...|.|:|
Mouse  2036 ERTNQLK--------------IIEISSERMPKNACGDKPPGSDR 2065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	11/52 (21%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
Pdzd2	NP_001074533.1	PDZ_signaling	335..416	CDD:238492
		PDZ_signaling	591..672	CDD:238492
		PDZ_signaling	729..813	CDD:238492
		PHA03307	1050..>1355	CDD:223039
		PHA03247	<1197..1562	CDD:223021	17/81 (21%)
		PDZ_signaling	2581..2663	CDD:238492
		PDZ	2709..2791	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900