DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and Pdlim5

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_006233474.1	Gene:	Pdlim5 / 64353	RGDID:	621076	Length:	624	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	108/505 - (21%)
Similarity:	176/505 - (34%)	Gaps:	153/505 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PWGFRLVGGADYDYPLTVVKVTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMG-SGSV 77
            ||||||.||.|::.|||:..:.:|..|.:|.:|:.|:::.|:..:|..:||.||...|.. :||:
  Rat    13 PWGFRLQGGKDFNMPLTISSLKDGGKASQAHVRIGDVVLSIDGISAQGMTHLEAQNKIKACTGSL 77

  Fly    78 FYFGVYRENEEDAYECLKKFPTS--EGSLTKSPMPTISPSP--TPSLSQLTETTN-ARTPEPEPF 137
                  ....:.|....|..|.:  :|    .|...:.|.|  :|::|::|.||| |....|.||
  Rat    78 ------NMTLQRASAAAKSEPVAVQKG----EPKEVVKPVPITSPAVSKVTSTTNMAYNKVPRPF 132

  Fly   138 ----------VPLPRE-----------------LAAAT-------------------------MA 150
                      :|.|..                 :||.|                         ..
  Rat   133 GSVSSPKVTSIPSPSSAFTPAHAATSSHASPPPVAAVTPPPLSASGLHASANPSAAQCSSPPNTG 197

  Fly   151 APAVEVD-----VDVLAECRQPMSEVHSEEKRGDV---NGHDAPGQADEGGLPVENLYLPDLPDR 207
            .|||.|.     ..|.:|..|.::|......:||:   ||:  ||          .:.:|  |.|
  Rat   198 KPAVHVPRQPTVTSVCSESAQELAEGQRRGSQGDIKQQNGN--PG----------TVKIP--PKR 248

  Fly   208 PCSALSERQEIKLVEEEIAAVLSGESEVLKEHNVLGVNFYRIFPKPGVCMSSDVLRSLNEEVTKT 272
            |     .|:.|  ||.                   ...||.|              ..:.:.:|.
  Rat   249 P-----PRKHI--VER-------------------NTEFYHI--------------PTHSDASKK 273

  Fly   273 KLEKDKENRQWSTFLQRPNRPVPKSKQSLEAERRAANAYKVTIVKSAPREKSPMPEAKPAP-KEA 336
            :|.:|.|:  |        ||...:.|| .:.|..|.......:|.:..:.:....:.|.| :::
  Rat   274 RLIEDTED--W--------RPRTGTTQS-RSFRILAQITGTEHLKESENDNAKKANSTPEPSQQS 327

  Fly   337 TPPKEVEKKEEEPVPEEVVEPEPEPEKDEEPLPTDSEVPNLEQLPETELPDEQPEKSDAPKEVCE 401
            ..|....:..|.|.....|..........:|:.:.|     .:.|..:.|::.........:|..
  Rat   328 ASPLSAAESLESPGSNRPVVAGLRSAAAFKPVGSTS-----VKSPSWQRPNQAGTSMRKCGDVRS 387

  Fly   402 PEVVIQTEPGSPD----GNEASDGPAGATPPAEPITPVPVKSEEELALER 447
            ....|.....:|.    .|.||....||  |.:|....|..|:::..::|
  Rat   388 QHTQICFGSKAPSTGRISNSASSSGTGA--PMKPAVGPPQPSDQDTLVQR 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	24/61 (39%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
Pdlim5	XP_006233474.1	PDZ_signaling	10..82	CDD:238492	26/74 (35%)
		DUF4749	214..305	CDD:292558	31/155 (20%)
		LIM1_ENH	448..499	CDD:188837
		LIM	507..558	CDD:295319
		LIM	566..620	CDD:295319
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100