DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and PDLIM2

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_067643.3	Gene:	PDLIM2 / 64236	HGNCID:	13992	Length:	602	Species:	Homo sapiens

Alignment Length:	362	Identity:	95/362 - (26%)
Similarity:	133/362 - (36%)	Gaps:	126/362 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PWGFRLVGGADYDYPLTVVKVTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSGSVF 78
            |||||:.||.|:..|:.|.||.|...|.:|.||..||||.||..:|..:.|.||...|..|.|..
Human   262 PWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHAEAQSKIRQSPSPL 326

  Fly    79 YFGVYRE--------NEEDAYECL--------KKFPTSEGSLTKS-PMPT-ISP------SPTPS 119
            ...:.|.        |.:.:.|.|        :.:..|:.||..| ..|| :||      ||.||
Human   327 RLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRSSYSSPTSLSPRAGSPFSPPPS 391

  Fly   120 LSQLT-ETTNARTPEPEPFVPLPRELAAATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGDVNGH 183
            .|.|| |...:|:     |..|     |.:...||    .|.|:...:|.|.            .
Human   392 SSSLTGEAAISRS-----FQSL-----ACSPGLPA----ADRLSYSGRPGSR------------Q 430

  Fly   184 DAPGQADEGGLPVENLYLPDLP----DRPCSALSERQEIKLVEEEIAAVLSGESEVLKEHNVLGV 244
            ...|:|.:..:    |.||..|    .||          .:..|..:.:|..:|||.|
Human   431 AGLGRAGDSAV----LVLPPSPGPRSSRP----------SMDSEGGSLLLDEDSEVFK------- 474

  Fly   245 NFYRIFPKPGVCMSSDVLRSLNEEVTKTKLEKDKEN----RQWSTF--LQRPNRPVPKSKQSLEA 303
                                        .|::::|.    ||.|:|  ||          ::|||
Human   475 ----------------------------MLQENREGRAAPRQSSSFRLLQ----------EALEA 501

  Fly   304 ERRAANAYKVTIVKSAPREKSPMPEAKPAPKEATPPK 340
            |.|....   ..:.|:...:|.:|.::..   |||||
Human   502 EERGGTP---AFLPSSLSPQSSLPASRAL---ATPPK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	28/60 (47%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
PDLIM2	NP_067643.3	PDZ_signaling	259..330	CDD:238492	30/67 (45%)
		DUF4749	<462..505	CDD:292558	17/87 (20%)
		LIM_Mystique	536..588	CDD:188833
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8352
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41321
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.960