DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and Slc9a3r1

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_067605.1	Gene:	Slc9a3r1 / 59114	RGDID:	708538	Length:	356	Species:	Rattus norvegicus

Alignment Length:	424	Identity:	89/424 - (20%)
Similarity:	134/424 - (31%)	Gaps:	132/424 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 QEIKLVEEEIAAVLSGESEVLKEHNVLGVNFYRIFPKPGVCMSSDVLRSLNEEVTKTKLEKDKEN 280
            |.|:|||....|..||                        .::.|.|..:|.|      ..:||.
  Rat    37 QFIRLVEPGSPAEKSG------------------------LLAGDRLVEVNGE------NVEKET 71

  Fly   281 RQWSTFLQRPNRPVPKSKQSLEAERRAANAYKVTIVKSAPREKSPMPEAKPAPKEATPPKEVEKK 345
            .|                |.:...|.|.||.::.:|.         ||.          .|..||
  Rat    72 HQ----------------QVVSRIRAALNAVRLLVVD---------PET----------DEQLKK 101

  Fly   346 EEEPVPEEVVEPEPEPEKDEEPLPTDSEVPNLEQLPETELPDEQPEKSDAPKEVCEPEVVIQTEP 410
            ...|:.||::..:.:.|..|.|...|           |:...:|.|...:..|.||....:.|..
  Rat   102 LGVPIREELLRAQEKSEHTEPPAAAD-----------TKKAGDQNEAEKSHLERCELRPRLCTMK 155

  Fly   411 GSPDG---NEASDGPAGATPPAEPITPV-PVKSEEELALERQLADVQRQLAALSSLPSTIQSTLD 471
            ..|:|   |..||    .:.|.:.|..| |....|...|..|...|:.....:..
  Rat   156 KGPNGYGFNLHSD----KSKPGQFIRAVDPDSPAEASGLRAQDRIVEVNGVCMEG---------- 206

  Fly   472 AVTKQLADLLPTIKLQQQEKQLPQIDENSGNEEQVEEGVTTATNTINTAGETEDAGKDISISGSD 536
               ||..|::..||....|.:|..:|:                       ||::..|...::.|.
  Rat   207 ---KQHGDVVSAIKAGGDEAKLLVVDK-----------------------ETDEFFKKCRVTPSQ 245

  Fly   537 NPPVGPCE---SNEDRCDANDREVAEISRSTDDNR--LAKDKKKDLDQEQKQQQQQQQEPLSEEQ 596
            ....||..   ||.:....|.|| |.:..:::..|  ||:....|..:|...|...::...:|..
  Rat   246 EHLDGPLPEPFSNGEIQKENSRE-ALVEPASESPRPALARSASSDTSEELNAQDSPKRHDSTEPS 309

  Fly   597 NFKKQKRHDVIEELEEHLV----RKNNPRRSKRA 626
            :.....  |.|.:....|.    |.:..|.||||
  Rat   310 STSSSS--DPILDFNISLAVAKERAHQKRSSKRA 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
Slc9a3r1	NP_067605.1	PDZ_signaling	12..91	CDD:238492	20/99 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..142		7/39 (18%)
		PDZ_signaling	149..228	CDD:238492	21/95 (22%)
		EBP50_C	232..356	CDD:286142	27/113 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	265..356		20/80 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900