DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zasp67 and Pdzk1

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001139473.1	Gene:	Pdzk1 / 59020	MGIID:	1928901	Length:	519	Species:	Mus musculus

Alignment Length:	618	Identity:	127/618 - (20%)
Similarity:	216/618 - (34%)	Gaps:	166/618 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DIKMCRFDNVPWGFRLVGGADYDYPLTVVKVTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAH 68
            :.|:.:.:...:||.|....|.|..|..| :.|||.|::|||...|.::|||........|.:..
Mouse     9 ECKLSKQEGQNYGFFLRIEKDTDGHLIRV-IEEGSPAEKAGLLDGDRVLRINGVFVDKEEHAQVV 72

  Fly    69 RLIMGSGSVFYFGVYRENEEDAYE-------CLKKFPTS--EGSLT-KSPMP----TISPSPTPS 119
            .|:..||:.....|.   :.|:||       .||:...|  |.:|. |.|.|    .:.|...|.
Mouse    73 ELVRKSGNSVTLLVL---DGDSYEKAVKNQVDLKELDQSQREAALNDKKPGPGMNGAVEPCAQPR 134

  Fly   120 LSQLTETTNA-----RTPEPEPFVPLPRELAAATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGD 179
            |..|.:..|:     :|.:.:..|.|      ..:....|.:...|||           ::...:
Mouse   135 LCYLVKEGNSFGFSLKTIQGKKGVYL------TNIMPQGVAMKAGVLA-----------DDHLIE 182

  Fly   180 VNGHDAPGQADEGGLPVENLYLPDLPDRPCSALSERQEIKLVEEEIAAVLSGESEVLKEHNVLGV 244
            |||.:           |||....::.::...: ..|....||::|.|
Mouse   183 VNGEN-----------VENASHEEVVEKVTKS-GSRIMFLLVDKETA------------------ 217

  Fly   245 NFYRIFPKPGVCMSSDVLRSLNEEVTKTKLEKDKENRQWSTFLQRPNRPVPKSKQSLEAERRAAN 309
                              |..:|:.|:.|       |:.::....|::|      .:...::.:|
Mouse   218 ------------------RCHSEQKTQFK-------RETASLKLLPHQP------RVVVIKKGSN 251

  Fly   310 AYKVTIVKSAPREKSP-MPEAKP-APKEATPPKE------VEKKEEEPVPEE-VVEPEPEPEKDE 365
            .|.. .:::.|.:|.. :.:.:| :|.||...|.      |..|..|.:..: |||...:.....
Mouse   252 GYGF-YLRAGPEQKGQIIKDIEPGSPAEAAGLKNNDLVVAVNGKSVEALDHDGVVEMIRKGGDQT 315

  Fly   366 EPLPTDSEVPNLEQLPETELPDEQPEKSDAPKEVCEPEVVIQTEPGSPDGNEASDGPAGATPPAE 430
            ..|..|.|..::..|...           :|...|:.:.:       |:|: ..:|||....|.|
Mouse   316 TLLVLDKEAESIYSLARF-----------SPLLYCQSQEL-------PNGS-VKEGPAPIPAPLE 361

  Fly   431 PITPVPVKSEE--ELALERQLADVQR---QLAALSSLPSTIQSTLDAVTKQLADLLPTIKLQQQE 490
            .....|.:..|  :..|.|.|.:...   .|.|:...|.:.       .|::....|..|...:.
Mouse   362 ATGSEPTEDAEGHKPKLCRLLKEDDSYGFHLNAIRGQPGSF-------VKEVQQGGPADKAGLEN 419

  Fly   491 KQLPQIDENSGNEEQVEEGVTTATNTINTAGE------------TEDAGKDISISGSDNPPV--G 541
            :.:  |.|.:|...| ||........|.::|:            :....|.|.|..|...|:  |
Mouse   420 EDV--IIEVNGENVQ-EEPYDRVVERIKSSGKHVTLLVCGKMAYSYFQAKKIPIVSSMAEPLVAG 481

  Fly   542 P-------CESNEDRCDANDREVAEISRSTDDN 567
            |       .||..|...|.||.::..|.|:.::
Mouse   482 PDEKGETSAESEHDAHPAKDRTLSTASHSSSNS 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	21/70 (30%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
Pdzk1	NP_001139473.1	PDZ_signaling	7..87	CDD:238492	23/78 (29%)
		PDZ	132..212	CDD:214570	18/108 (17%)
		PDZ_signaling	242..320	CDD:238492	16/78 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..374		7/26 (27%)
		PDZ_signaling	376..455	CDD:238492	17/88 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	479..519		10/36 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900