DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and grip2a

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_017212845.1	Gene:	grip2a / 568084	ZFINID:	ZDB-GENE-081104-132	Length:	1100	Species:	Danio rerio

Alignment Length:	691	Identity:	138/691 - (19%)
Similarity:	227/691 - (32%)	Gaps:	235/691 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WGFRLVGGADYDY----PLTVVKVTEGSIADEAG-LRVEDIIVRINDTAATPLTHDEAHRLIMGS 74
            :||.|.||...|:    ||.|..|..|..||..| ||..|.::.:|..|.....|.:|..|||.|
Zfish   199 FGFVLRGGFHEDWHKARPLVVTYVRPGGPADREGTLRAGDRVLSVNGVAVNRQKHADALTLIMQS 263

  Fly    75 GSVFYFGVYRENEEDAYECLKKFPTSEGSLTKSPMP---TISPSPTPSLSQLTETTNARTPEPEP 136
            ....:|.:       .|:.:..     .|:.||..|   .|:.|....|.....|:..|.
Zfish   264 SQEAFFLI-------EYDIMVM-----DSVQKSSGPLQVDIARSAGSVLGLSLSTSLYRN----- 311

  Fly   137 FVPLPRELAAATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGDVNGHDAPGQADEGGLPVENLYL 201
                 :::.......||...|     .|    ..:|:    ||:                 .|.:
Zfish   312 -----KQVITIQKIKPASVAD-----RC----GALHA----GDI-----------------LLAI 341

  Fly   202 PDLPDRPCSALSERQEIKLVEEEIAAVLSGESEVLKEHNVLGVNFYRIFPKPGVCMSSDVLRSLN 266
            ..:....||.:..:|           :||..||:.|                     .::|.||:
Zfish   342 DGMSTEHCSLMEAQQ-----------LLSSSSELTK---------------------LEILPSLH 374

  Fly   267 EEVTKTKLEKDKENRQWST----------FLQRPN-----RPVPKSK---QSLEAERRAANAYKV 313
            ......::::..: |||.:          |.:.|:     .|.|..:   ..:.|.....::|..
Zfish   375 SSQDTVRVQRSCQ-RQWDSSENYTNALPAFQKTPSAWSQTTPTPSHRSVSSGVSANTSGFHSYNC 438

  Fly   314 TIVKSAPR--EKSPMPEAKPAPKEATPPKEVEKKEEEPVPEEVVEPEPEPEKDEEPLPTDS---- 372
            ....:.|.  ..|.:|....:|:.:...:...:||               .|....|.:.:
Zfish   439 GSQSAYPNTYPSSTLPSYPSSPRCSATKRRHRRKE---------------HKSSLSLASSTVGAG 488

  Fly   373 -EVPNLEQLPETELPDEQPEKSDAPKEVCEPEVVIQTEPGSPDGNEASDGPAGATP---PA---- 429
             :|.:||                      ..||:::.:|.:..|.:...|.....|   ||
Zfish   489 GQVVHLE----------------------SAEVLLRGDPLTGFGLQLQGGVFATEPLSAPAAIRF 531

  Fly   430 -EPITPVPVKSEEELALER----QLADVQRQLAALSSLPSTIQSTLDAVTKQLAD--LLPTIKLQ 487
             ||.||.          ||    |:.|   ::.:::.:| |...||:...:.|.|  |...|.|:
Zfish   532 IEPDTPA----------ERCGVLQVGD---RILSINGIP-TEDGTLEEANQLLRDAALANKIALE 582

  Fly   488 QQEKQLPQIDENSG-------NEEQVEEGVTTATNTINTAGETEDAGKDISIS----GSDNPPVG 541
            .:......:..:||       ....||.|:|.:.        ::.|||.:.||    ||....:|
Zfish   583 VEFDVAESVIPSSGTFQVKLPKRRGVELGITISA--------SKKAGKPLIISEIQKGSIAHRIG 639

  Fly   542 PCESNEDRCDANDREVAEISRSTDDNRLAKDKKKDLDQEQKQQQQQQQEPLSEEQNFKKQKRHDV 606
            ..|       ..||.:|     .|:.||     .:...|:.....||.|.:.:   .:.||..|.
Zfish   640 TLE-------PGDRLLA-----IDNVRL-----DNCGMEEAMMVLQQAEGMVK---LRIQKDEDN 684

  Fly   607 IEELEE--------HLVRKNNP-----RRSKRAFGPLVPSS 634
            ::|||.        .|.|...|     ..::..|.|::.||
Zfish   685 LDELESSGSVIFTVELKRHGGPLGITISGTEEPFNPILISS 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	24/64 (38%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
grip2a	XP_017212845.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900