DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zasp67 and PARD3

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_062565.2	Gene:	PARD3 / 56288	HGNCID:	16051	Length:	1356	Species:	Homo sapiens

Alignment Length:	929	Identity:	163/929 - (17%)
Similarity:	301/929 - (32%)	Gaps:	308/929 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DNVPWGFRLV-----GGADYDYPLTVVKVTEGSIADEAGL-RVEDIIVRINDTAATPLTHDEAHR 69
            |..|.|..:|     ||....  |.|.::.:|..|:...| |..|.||||||........::|..
Human   280 DGGPLGIHVVPFSARGGRTLG--LLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQH 342

  Fly    70 LIMGS--GSVFYFGVYRENEEDAYECLKK-----------FPTSE------------GSLTKSPM 109
            :...:  ..:.:|.|.....::.||.|.:           .|.|:            .::.::|.
Human   343 MFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPR 407

  Fly   110 PTISPSPTPSLSQLTETTNARTPEPEPFVPLPRELAAATMAA--------PAVEVDV-------- 158
            ....|....|.|:|..:.:.....|......|:.:.:.|:::        ..:.:.:
Human   408 LNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLG 472

  Fly   159 ------DVLAECRQPM--------------SEVHSEEKRGDVNGHDAPGQADEGGLPV------- 196
                  ||......|:              ..:.:.::..:|||.|..|::.|..:.:
Human   473 FSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKME 537

  Fly   197 ----------ENLYLP-DLPDRPCSALSERQEIKLVEEEIAAVLSGESEVL-------------- 236
                      |:.:.| :|...| |.:...:|.|..:|:|.....|..|.|
Human   538 GTVSLLVFRQEDAFHPRELNAEP-SQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGL 601

  Fly   237 ----------KEHNVLGVNFYRIFPKP---GVCMSSDVLRSLNEEVTKTKLEK--DKENRQWSTF 286
                      :.|..||     ||.|.   |...|.|....:|:::.....|.  .|.|:.....
Human   602 GVSVKGNRSKENHADLG-----IFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMET 661

  Fly   287 LQRPNRPVPKSKQSLEAERR-------AANAYKVTIVKSAPREKSPMPEAKPAP----KEATPPK 340
            |:|        ..|.|..:|       |....|...:||        |.:.|.|    :.|...:
Human   662 LRR--------SMSTEGNKRGMIQLIVARRISKCNELKS--------PGSPPGPELPIETALDDR 710

  Fly   341 E----------VEKKEEEP--------VPEEVVEPEPEPEKDEEPLPTDSEVPNLEQLPETELPD 387
            |          :|..:|.|        :..|..:.:..|..:   :|.|..|    .:.:..||.
Human   711 ERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLSPTVN---MPQDDTV----IIEDDRLPV 768

  Fly   388 EQPEKSDAPKEVCEPEV-VIQTEPGSPDGNEASD-GPAGATPPAEPI----------TPVPVKSE 440
            ..|..||........:| .:..:.|:......|| .....:|..:|:          ..:..|..
Human   769 LPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRT 833

  Fly   441 EELALERQLADVQRQLAALSSLPSTIQSTLDAVTKQLA-----DLLPTIKLQQQ----------- 489
            ::.:...||..|:.:.:....|....::.|:.|..|.|     |:.|::.|::.
Human   834 KQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVA 898

  Fly   490 ----------EKQLPQI------------------------DENSGN---EEQVEEGVTTATNTI 517
                      .:..|:|                        |::.|.   ||..||...:...::
Human   899 EVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETLEEDTEESSRSGRESV 963

  Fly   518 NTAGETEDAGKDISISGSDNPPVGPCESNEDRCDANDREVAEISRSTDDNRLAKDKKKDLDQEQK 582
            :||.:......:..::|           |:::.|..||:         .::..|:||||.|:|:.
Human   964 STASDQPSHSLERQMNG-----------NQEKGDKTDRK---------KDKTGKEKKKDRDKEKD 1008

  Fly   583 QQQQQQ--QEPLSEEQNFKKQKRHDVIE-----ELEEHLVRKNNPRRSKRAFGPLVPSSERPLVL 640
            :.:.::  .:.|.:...|.|.::.|.||     :::|....:....|.|:       ..||   :
Human  1009 KMKAKKGMLKGLGDMFRFGKHRKDDKIEKTGKIKIQESFTSEEERIRMKQ-------EQER---I 1063

  Fly   641 PGGRRWYRPKDAYNDEFIAE------TLSAQAELITG------STLGVN---------------F 678
            ....|.:|.:.|...:: ||      |.....||:.|      .::.:|               :
Human  1064 QAKTREFRERQARERDY-AEIQDFHRTFGCDDELMYGGVSSYEGSMALNARPQSPREGHMMDALY 1127

  Fly   679 MKYQKPERK----IDLNRS 693
            .:.:||...    :|.|||
Human  1128 AQVKKPRNSKPSPVDSNRS 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	20/71 (28%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558	13/72 (18%)
PARD3	NP_062565.2	DUF3534	1..146	CDD:288873
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..100
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..262
		PDZ_signaling	272..347	CDD:238492	20/68 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..448		7/39 (18%)
		PDZ_signaling	465..544	CDD:238492	9/78 (12%)
		PDZ_signaling	588..681	CDD:238492	18/105 (17%)
		Interaction with PRKCI and PRKCZ. /evidence=ECO:0000250\|UniProtKB:Q9Z340	712..936		33/230 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..886		6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	932..1025		21/112 (19%)
		Interaction with FRMD4A. /evidence=ECO:0000250\|UniProtKB:Q99NH2	935..1356		47/243 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1129..1356		6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900