DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and grip2b

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_021325304.1	Gene:	grip2b / 562290	ZFINID:	ZDB-GENE-070705-172	Length:	1086	Species:	Danio rerio

Alignment Length:	634	Identity:	129/634 - (20%)
Similarity:	214/634 - (33%)	Gaps:	180/634 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IKMC-RFDNVPWGFRLVGGADYDY----PLTVVKVTEGSIADEAG-LRVEDIIVRINDTAATPLT 63
            |::| :.:...:||.:.|||..|:    ||.|..|..|..||..| |:..|.|:.::.......|
Zfish   146 IEICLQKEGNSFGFVMRGGAHEDWHKSRPLVVTHVRPGGPADREGTLKSGDRILSVDGVVLHSAT 210

  Fly    64 HDEAHRLIMGSGSVFYFGVYRENEEDAYECLKKFPTSEGSLTKSPMPTISPSPTPSLSQLTETTN 128
            |.:|..::...|....|.:    |.|                              :|.:...||
Zfish   211 HSDALVVLTQCGQEALFQI----EYD------------------------------VSIMDSVTN 241

  Fly   129 ARTPEPEPFVPLPRELAAATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGDVNGHDAPGQADEGG 193
            |..       ||..|:|.|..|:..|.:   ..|..|...:.|..:.|.|.|...       .|.
Zfish   242 ASG-------PLLVEIAKAPGASLGVTL---TTALHRNKQAIVIDKIKPGSVVDR-------SGA 289

  Fly   194 LPVEN--LYLPDLPDRPCSALSERQEIKLVEEEIAAVLSGESEVLKEHNVLGVNFYRIFPKPGVC 256
            |.|.:  |.:.......||.|...|.:....::.      :.|:|..|..      |:..||
Zfish   290 LHVGDHILSIDGTSTEHCSLLEATQLLASTSDQT------KLEILPAHQT------RLPGKP--- 339

  Fly   257 MSSDVLRSLNEEVTKTKLEKDKENRQWSTFL-----QRPNRPVPKSKQSLEAERRAANAYKVTIV 316
              .|.:          |::|......|...:     |.|......:..|..:...::..|..::|
Zfish   340 --QDTV----------KVQKSDHPHCWDPCVNYCHSQHPGHCKTSTWTSASSNPSSSQDYCKSVV 392

  Fly   317 KS------------APREKSPMPEAKP--APKEATPPKEVEKKEEEPVPEEVVEPEPEPEKDEEP 367
            .|            ..:..|.:|.|.|  :|:.:...:...|||.              :.....
Zfish   393 CSNFSPGSTTTSGMTSQGSSTLPRAAPPMSPRNSMLKRRQRKKEH--------------KSSSVS 443

  Fly   368 LPTDSEVPNLEQLPETELPDEQPEKSDAPKEVCEPEVVIQTEPGSPDGNEASDGP-AGATPPAEP 431
            |.:.|..|. .|:..||                ..||.::.:|.:..|.:...|. |..|..|.|
Zfish   444 LASSSVGPG-GQIVHTE----------------SSEVTLRGDPLNGFGVQLQGGIFATETLSAPP 491

  Fly   432 ITPV--PVKSEEELALERQLADVQRQLAALSSLPSTIQSTLDAVTKQLAD--LLPTIKLQQQEKQ 492
            :...  |..|.|...| .|:.|   ::.:::.:| |...||:...:.|.|  |...:.|:.:...
Zfish   492 LIRFIEPDSSAERCGL-LQVGD---RVLSINGIP-TEDGTLEEANQLLRDAALANKVSLEIEFDV 551

  Fly   493 LPQIDENSG-------NEEQVEEGVTTATNTINTAGETEDAGKDISIS----GSDNPPVGPCESN 546
            ...:..:||       .:..||.|:|.:.        ::..|:.:.||    ||.....|..|..
Zfish   552 AESVVPSSGTFHVKLQKKRGVELGITISA--------SKKPGEPLIISDIKKGSMAHRTGTLEPG 608

  Fly   547 E----------DRCDANDREVAEISRSTDDNRLAKDK-KKDLDQEQKQQ 584
            :          :.|...|  .|:|.:.::|  |.|.| :||.|...:|:
Zfish   609 DKLLAIDNIRLENCSMED--AAQILQQSED--LVKLKIRKDEDNSDEQE 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	22/75 (29%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
grip2b	XP_021325304.1	PDZ_signaling	45..127	CDD:238492
		PDZ	144..232	CDD:214570	25/89 (28%)
		PDZ_signaling	245..328	CDD:238492	22/98 (22%)
		PDZ_signaling	462..548	CDD:238492	23/90 (26%)
		PDZ_signaling	561..643	CDD:238492	19/93 (20%)
		PDZ_signaling	659..740	CDD:238492
		Peptidase_S41	672..>841	CDD:321971
		PDZ_signaling	970..1050	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910