DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and grid2ipb

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_009304908.1	Gene:	grid2ipb / 559717	ZFINID:	ZDB-GENE-040724-161	Length:	1383	Species:	Danio rerio

Alignment Length:	729	Identity:	138/729 - (18%)
Similarity:	220/729 - (30%)	Gaps:	271/729 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WGFRLVGGADYDYPLTVVKVTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSGSVFY 79
            :||.|.|.|    |:.:..|..||.|:..||:..|.|:.:|.......:|::...::.|||::..
Zfish   346 FGFTLRGHA----PVWIDSVMPGSPAEACGLKTGDRILFLNGLDMRNCSHEKVVSMLQGSGAMPS 406

  Fly    80 FGVYRENEEDAYECLKKFPTSEGSLTKSPMPTISPSPTPSLSQLTETTNARTPEPEPFVPLPREL 144
            . |..|...|       :|.|:..                            ||..|..|..|
Zfish   407 L-VVEEGPVD-------YPQSDSE----------------------------PEETPSAPRSR-- 433

  Fly   145 AAATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGDVNGHDAPGQADEGGLPVENLYLPDLPDRPC 209
                  :||:. .:..:||...|...||..
Zfish   434 ------SPALS-SLQWVAEILPPSIRVHGR----------------------------------- 456

  Fly   210 SALSERQEIKLVEEEIAAVLSGESEVLKEHNV--LGVNFYRIFPKPGVCMSSDVLRSL----NEE 268
             ..|::.|..|..:|...:........:..||  |.|:.:.:...|...:....:..|    .:|
Zfish   457 -TFSQQLEHLLTLQERYTICKALETFFQHRNVDTLIVDVFPVLDTPAKQLIWQFIYQLLTYEEQE 520

  Fly   269 VTKTKLEKDKENRQWSTFLQRPNRPVPKSKQSLEAE-----RRAANAYKV--TIVKSAPREKSP- 325
            ..|||:.:         ||         ..:|.|.|     .|.:::.:|  |..|:..||:|.
Zfish   521 HCKTKIAR---------FL---------GFKSAEPEVGAETHRRSSSMRVSGTSHKNTVRERSSD 567

  Fly   326 --MPEAKPAPKEATPPKEVEKKEEEPVPEEVVEPEPEPEKDEEPLPTDSEVPNLEQLP--ETELP 386
              :..........|.|               |.||.....|....|   |.|:|..:.  .|||.
Zfish   568 DCIIGTHLGMGTFTDP---------------VTPEERQCGDGTSFP---ESPDLSHMTGVYTELG 614

  Fly   387 DEQPEKS-------DAPKE----VCEPEVVIQTEPGSPDGNEAS--------------------- 419
            :..|.||       .:|:.    :.|.....|:...|..||..|
Zfish   615 NVYPVKSSQSLQSHSSPRAAGMGLAESNTYTQSFTHSTAGNRKSGLSLTWTDSFPGPQFETYQQT 679

  Fly   420 ---------------DGPAGATPPAEPITPVPVKSEEELALERQLADVQRQLAALSSLPSTIQST 469
                           |.|..:..|::.::|:|                ||:.....|.|...:.|
Zfish   680 VASPDSVDSNPYVSLDSPPASPLPSDELSPLP----------------QRRKLFTFSRPPRSRDT 728

  Fly   470 ---LDAVTKQLADLLPTIKLQQQEKQLPQIDENSGNEE-------QVEEGVTTATNTINTAGETE 524
               |||:::||.            .::..:|:..|.|.       |.|:.|....:.:::|...:
Zfish   729 DKFLDALSEQLG------------HRVNIVDDFKGGENDYEEMSFQDEQEVNMLPHELSSASSED 781

  Fly   525 DAGKDISI-----SGSDN---------PPVGPCESNEDRCDANDREVAEISRSTDDNRLAKDKKK 575
            .:..|.|.     ||||:         ||..|.:                  .||.........:
Zfish   782 HSSSDDSTSVSYSSGSDHIPPPPQSPPPPPPPLQ------------------FTDSPSPLPITPE 828

  Fly   576 DLDQEQKQQQQQQ--QEPLSEEQNF--KKQKRHDVIEELEEHLVRKNNPRRSKRAFGPLVPSSER 636
            .|.|.....|...  ..|....:.|  .:...|.|:...||...:.::||||...     |||:.
Zfish   829 HLPQPPPAFQHHPIIAPPPPPPRPFLANRPSLHKVLPTREELRAQHSHPRRSSPQ-----PSSQP 888

  Fly   637 PLVLPGGRRWYRPK 650
            .|.|      ::||
Zfish   889 ILQL------HQPK 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	17/59 (29%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
grid2ipb	XP_009304908.1	PDZ_signaling	9..69	CDD:238492
		PDZ_signaling	80..156	CDD:238492
		HN_L-delphilin-R1_like	183..262	CDD:259820
		PDZ_signaling	335..410	CDD:238492	20/68 (29%)
		HN_L-delphilin-R2_like	451..530	CDD:259821	16/123 (13%)
		FH2	995..1360	CDD:280362
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900