DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and lnx2a

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001106696.2	Gene:	lnx2a / 553331	ZFINID:	ZDB-GENE-060228-2	Length:	737	Species:	Danio rerio

Alignment Length:	399	Identity:	83/399 - (20%)
Similarity:	127/399 - (31%)	Gaps:	133/399 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GFRLVGGADYDYPLTVVKVTE----GSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSGS 76
            |..:|||  .:.||..|.:.|    |.||.:..|...|.|:::|:...:.:.|:.|...:....:
Zfish   283 GISIVGG--NETPLINVVIQEVYRDGVIARDGRLLAGDQILQVNNVDISNVPHNFARSTLARPCA 345

  Fly    77 VFYFGVYRENEEDAYECLKKFPTSEGSLTKSPMPTISPSPTPSLSQLT----ETTN-------AR 130
            .....|.||....|               :.|..|.||..:|:..::|    |::.       .|
Zfish   346 TLQLTVLRERRCSA---------------RPPAATASPKGSPASIRITLHKRESSEQLGIKLVRR 395

  Fly   131 TPEPEPFV---------------------------------PLPRELAAATMAAPAVEVDVDVLA 162
            |.|...|:                                 |   ||||..:.|....|::.:..
Zfish   396 TDEAGVFILDLLEGGLAAKDGRLCSNDRVLAVNEHDLRHGTP---ELAAQIIQASGERVNLLISR 457

  Fly   163 ECRQPMSEVHSEEKRGDVNGHD----APGQADEGGLPVENLYLPDLPDRPCSALSERQEIKLVEE 223
            ..:|.|:.........|:..||    .|..|...  ||.:|:|.    |..:.....|.:...|:
Zfish   458 SSKQTMAVHTGSTLTRDIWSHDHIPPLPSTATPS--PVPSLHLA----RSSTQRDLSQCVNCKEK 516

  Fly   224 EIAAVLSGESEVLKE-HNVLGVN-------------FYRIFPKPGVCMS-------SDVLRSLNE 267
            .|.        |.|| |..||:.             .:....:|..|:|       .|||.|:
Zfish   517 HIT--------VKKEPHESLGMTVAGGRGSKSGELPIFVTSVQPHGCLSRDGRIKRGDVLLSI-- 571

  Fly   268 EVTKTKLEKDKENRQWSTFLQRPNRPVPKSKQSLEAERRAANAYKVTIVKSAPREKSPMPEAKPA 332
                        |.|..|:|.. :..|...|.|..:......|.:||:|           |....
Zfish   572 ------------NGQDLTYLSH-SEAVGTLKSSATSCSVQLKALEVTMV-----------EEPGL 612

  Fly   333 PKEATPPKE 341
            .:|..||.|
Zfish   613 DEELLPPHE 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	17/62 (27%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
lnx2a	NP_001106696.2	zf-RING_2	49..87	CDD:290367
		PDZ	267..353	CDD:214570	18/71 (25%)
		PDZ_signaling	375..455	CDD:238492	13/82 (16%)
		PDZ_signaling	515..600	CDD:238492	22/107 (21%)
		PDZ_signaling	646..730	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900