DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and PDZK1

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_024303384.1	Gene:	PDZK1 / 5174	HGNCID:	8821	Length:	539	Species:	Homo sapiens

Alignment Length:	183	Identity:	46/183 - (25%)
Similarity:	72/183 - (39%)	Gaps:	35/183 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WGFRLVGGADYDYPLTVVKVTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSGSVFY 79
            :||.|..|::....: :..:..||.|:||||:..|::|.:|..:...|.||....:|...|....
Human   273 YGFYLRAGSEQKGQI-IKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTS 336

  Fly    80 FGVYRENEEDAYECLKKFP--------TSEGSLTKSPMPT------ISPSPT-------PSLSQL 123
            ..|..:..::.|......|        ...||:.::|.||      .||..|       |.|.:|
Human   337 LLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSPPDTTEEVDHKPKLCRL 401

  Fly   124 TE-------TTNARTPEPEPFVPL-----PRELAAATMAAPAVEVD-VDVLAE 163
            .:       ..||....|..|:..     |.:||........:||: |:||.|
Human   402 AKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDE 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	18/59 (31%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
PDZK1	XP_024303384.1	PDZ_signaling	27..107	CDD:238492
		PDZ	152..232	CDD:214570
		PDZ_signaling	261..340	CDD:238492	19/67 (28%)
		PDZ	395..475	CDD:214570	16/60 (27%)
		F1-ATPase_gamma	<457..>501	CDD:320933
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900