DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and Pdzd3

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001178925.1	Gene:	Pdzd3 / 500986	RGDID:	1559807	Length:	498	Species:	Rattus norvegicus

Alignment Length:	498	Identity:	94/498 - (18%)
Similarity:	154/498 - (30%)	Gaps:	170/498 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WGFRL---VGGADYDYPLTVVKVTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSGS 76
            :||.|   :|.||:    .|.:|..||.|...|||..|.|:.:|:.......:....|.|..||.
  Rat    60 FGFHLQQQLGKADH----VVCRVDPGSSAQRQGLREGDRILAVNNNIVEHEDYAVVVRYIRASGP 120

  Fly    77 VFYFGVYRENEEDAYECLKKFPTSEGSLTKSPMPTISPSPTPSLSQLTE---------TTNARTP 132
            .....|..::   .|:..:....:|.    .|.||::....|.|..:.:         |..||.|
  Rat   121 RVLLTVLAQH---VYDVTRAQQGNEA----FPCPTLASGVRPRLCHVVKDEGGFGFSVTHGARGP 178

  Fly   133 EPEPFVPLPRELAAATMAAPAVEVDVDVLAECRQPMSEVHSEEK---RGD-----VNGHDAPGQA 189
            .   ::.|....||.....|.....::|...|.:..:......|   .||     |.|.:...|.
  Rat   179 F---WLVLSAGGAAERAGVPPGARLLEVNGICVEKFTYNQLNRKLCQSGDRVTLLVAGPEVEEQC 240

  Fly   190 DEGGLPV-----ENLYLPDLPDRPCSALSERQEIKLVEEEIAAVLSGESEVLKEH----NVLGVN 245
            .:.|:|:     |...||..|  .|..:.:..:             |...:|:|.    ..||..
  Rat   241 HQLGMPLAAPLAEGWALPAKP--RCLNIEKGPQ-------------GFGFLLREEKGPDGRLGQF 290

  Fly   246 FYRIFP---------KPG---VCMSSDVLRSLNEEVTKTKLEKDKENRQWSTFLQRPNRPVPKSK 298
            .:.:.|         |.|   |.::.:.:..|..|.|.:::.  .:....|..:..|
  Rat   291 LWEVDPGLPADKAGMKAGDRLVAVAGESMDGLGHEETVSRIR--AQGSCVSLVVVDP-------- 345

  Fly   299 QSLEAER--RAANAYKVTIVKSAPREKSPMPEAKPAPKEATPPKEVEKKEEEPVPEEVVEPE--- 358
               ||:|  .......:..:::.....:|:.|.|..|.|.|                 |||.
  Rat   346 ---EADRFFSMVRLSPLLFLENTEIAAAPLAETKDLPVEDT-----------------VEPSGLA 390

  Fly   359 --------PEP----------------------------------------EKDEEPLPTDSEVP 375
                    |.|                                        |.:..|:..||::.
  Rat   391 GSRQCFLYPGPGGGYGFRLRCVASGPCLFISQVTPGGSAARAGLQMGDAILEVNGCPVGGDSDLD 455

  Fly   376 NLEQLPETELPDEQPEKSDAPKEVCEPEVVIQTEPGSPDGNEA 418
            .|:||.|                 .||.:.::..|.:..|:||
  Rat   456 TLQQLAE-----------------AEPPLRLKLAPRNSQGSEA 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	19/62 (31%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
Pdzd3	NP_001178925.1	PDZ_signaling	47..127	CDD:238492	21/70 (30%)
		PDZ_signaling	155..232	CDD:238492	15/79 (19%)
		PDZ	260..345	CDD:214570	15/101 (15%)
		PDZ_signaling	407..472	CDD:238492	10/81 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900