DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and Ldb3

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_006252699.3	Gene:	Ldb3 / 498587	RGDID:	1564875	Length:	771	Species:	Rattus norvegicus

Alignment Length:	491	Identity:	108/491 - (21%)
Similarity:	172/491 - (35%)	Gaps:	130/491 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PWGFRLVGGADYDYPLTVVKVTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSGSVF 78
            ||||||.||.|::.|||:.::|.||.|.::.|...|::|.|:......:||.||...|..:....
  Rat    57 PWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLEAQNKIKSASYNL 121

  Fly    79 YFGVYRENEEDAYECLKKFPTS-EGSLTKSPMPTISPSPTPSLSQLTETTNA--RTPEPEPFV-- 138
            ...:.:..        :..|.| .....:||:|.|.....|||.     ||:  .||.|.|..
  Rat   122 SLTLQKSK--------RPIPISTTAPPIQSPLPVIPHQKDPSLD-----TNSSLATPSPSPEARA 173

  Fly   139 ------------PLPRELAAATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGDVNGHDAPGQADE 191
                        ......:..::....:|....|| ....|:::..||..:|.|:....||.:.
  Rat   174 SPGTSGTLEFGDTFSSSFSQTSVCTSHMEASGPVL-PLGSPVAKASSEGTQGSVSPKVLPGPSQ- 236

  Fly   192 GGLPVENLYLPDLPDRPC---SALSERQEIKLVEEEIAAVLSGESEVLKEHNVLGVNFYRIFPKP 253
                      |.|.:.|.   ||.:.|:..::.:..:....||.       .:||.:.      |
  Rat   237 ----------PRLYNNPIGLYSAETLREMAQMYQMSLRGKASGA-------GLLGGSL------P 278

  Fly   254 GVCMSSDVLRSLNEEVTKTKLEKDKENRQW--------------------STFLQRPNRPVPKSK 298
            ...::.|....:.:.|.||:.:.:.|..:|                    :.::|.|:.
  Rat   279 VKDLAVDSASPVYQAVIKTQSKPEDEADEWARRSSNLQSRSFRILAQMTGTEYMQDPDE------ 337

  Fly   299 QSLEAERRAANAYKVTIVKSAP----REKSP-MPEAKPAPKEATP------------PKEVEKKE 346
               ||.||::     |.::.||    :..|| :|.:.|:|..|:|            ...|....
  Rat   338 ---EALRRSS-----TPIEHAPVCTSQATSPLLPASAPSPAAASPIAASPTLATAAAAHAVAASA 394

  Fly   347 EEPVPEEVVEPEPE-----PEKDEEPLPTDSEVPNLEQLPETELPDEQPEKSDAPKEVCEPEV-- 404
            ..|....|..|.|:     |.....|.|.          ..|...:.....:..|:.|....:
  Rat   395 AGPASSPVENPRPQASAYSPAAATSPAPA----------AHTSYSEGPAAPAPKPRVVTTASIRP 449

  Fly   405 -VIQTEPGSP--DGNEASDGPAGATP-PAEPITPVP 436
             |.|..|.||  ....|:..|...|| ||...||.|
  Rat   450 SVYQPVPASPYSPSPGANYSPTPYTPSPAPAYTPSP 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	25/60 (42%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
Ldb3	XP_006252699.3	PDZ_signaling	50..126	CDD:238492	25/68 (37%)
		DUF4749	240..341	CDD:406377	19/122 (16%)
		PHA03247	<426..576	CDD:223021	17/60 (28%)
		LIM1_ZASP_Cypher	595..646	CDD:188838
		LIM2_Enigma_like	654..705	CDD:188748
		LIM3_ZASP_Cypher	713..767	CDD:188844
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100