DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and Mhcl

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	125/553 - (22%)
Similarity:	193/553 - (34%)	Gaps:	148/553 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 RIFPKPGVCMSSDVLRSLNEE--VTKTKLEKDKENRQWSTFLQRPNRPVPKSKQSLEA------- 303
            |:.|...|..:.:.|::.|||  :.:.||||.:.:|.          .|....|.|||
  Fly  1374 RVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRS----------EVKAENQKLEAKLSELTV 1428

  Fly   304 ----ERRAAN-AYKVTIVKSAPREKSPMPEAKPAPKEATPPKEVEKKEEEPV----------PEE 353
                ||..|: |.:....::|.|.|..........|.....:..||.|.|.:          .:|
  Fly  1429 DLAEERSTAHIATERLEAETAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDE 1493

  Fly   354 VVEPEP----------------EPEKDEEPLPTDSEVPNLEQLPETELPDEQPEKSDAPKEVCEP 402
            ..|.|.                |.|..:..|.|..| .:||||...:...|. :.|||.:||.|.
  Fly  1494 DAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHE-HDLEQLVALKKHLEM-KLSDAYEEVVEQ 1556

  Fly   403 EVVI--QTEPGSPDGNEASDGPAGATPPAEPITPVPVKSEEELALERQLADVQRQLAALSSLPST 465
            ..|:  .........||.:|              :.:..||:.|....|...||:..|      .
  Fly  1557 RQVVGQWKRKAQKMTNEMND--------------LRMLLEEQNARNNLLEKKQRKFDA------E 1601

  Fly   466 IQSTLDAVTKQLADLLPTIKLQQQEKQLPQIDENSGNEEQVEEGVT-TATNTINTAGETEDAGKD 529
            .||..|||              :||:   |..|..|.|:.|.:... |...|:      .|...|
  Fly  1602 CQSLQDAV--------------RQER---QAKERYGREKDVLQAEKFTLEQTL------ADTRLD 1643

  Fly   530 ISISGSDNPPVGPCESNEDRCDANDREV-------------AEISRSTDD-NRLAKDKKKDLDQE 580
            :             |..|::..:..||:             |::.||.:: .|.||:::::||:.
  Fly  1644 L-------------EFKEEKLASLQRELEEMTFGGGTEEEFAQLRRSKNETERRAKEQEEELDEM 1695

  Fly   581 QKQQQQQQQEPLSEE---QNFKKQKRHDV---IEELEEHLVRKNNPRRSKRAFGPL-VPSSERPL 638
            ..|.|..:|..|..|   :..:|:.|.:.   .|||||  ||.|..::.|.....| ....||.|
  Fly  1696 AGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEE--VRGNGYKKIKALECQLETEHEERTL 1758

  Fly   639 VLPGGRRWYRPKDAYNDEFIAETLSAQAELITGSTLGVNFMKY---------QKPERKIDLNRSE 694
            :|.......|...:..|.   :.:...||......|..:..||         |....|.|.....
  Fly  1759 LLREKHELERRLSSMEDR---DRVDRDAEEALNQKLRRDLRKYKALLKDAQTQLERLKADTPGKT 1820

  Fly   695 VYKYLNPHL-DRAPVRGIEVRAPLVAAESDIRQ 726
            :.:.|...| |....|.:.::| ...||:::.:
  Fly  1821 LIRQLRNQLEDAESARSLAMKA-RQTAEAELTE 1852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558	9/54 (17%)
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769	62/268 (23%)
		COG1340	1565..1833	CDD:224259	72/328 (22%)
		coiled coil	1723..1734	CDD:293879	5/12 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900