DRSC/TRiP Functional Genomics Resources

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Protein Alignment Zasp67 and GRID2IP

DIOPT Version :9

Sequence 1:NP_648358.2 Gene:Zasp67 / 39148 FlyBaseID:FBgn0036044 Length:730 Species:Drosophila melanogaster
Sequence 2:NP_001138590.1 Gene:GRID2IP / 392862 HGNCID:18464 Length:1211 Species:Homo sapiens


Alignment Length:909 Identity:175/909 - (19%)
Similarity:266/909 - (29%) Gaps:384/909 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 NVPWGFRLVGGADYDYPLTVVKVTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSGS 76
            |..:||.|.|..    |:.:..|..||.||.|.|:..|.|:.:|.......:||:...::.|||:
Human   286 NKSFGFTLRGHG----PVWIESVLPGSPADNAALKSGDRILFLNGLDMRNCSHDKVVSMLQGSGA 346

  Fly    77 VFYFGVYRENEEDAYECLKKFPTSEGSLTKSPMPTISPSPTPSLSQLTETTNARTPEPEPFVPLP 141
            :....|        .|.|..|.:...||.       ||:|:.:|:.|                  
Human   347 MPTLVV--------EEGLVPFASDSDSLD-------SPNPSSALTSL------------------ 378

  Fly   142 RELAAATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGDVNGHDAPGQADEGGLPVENLYLPDLPD 206
                                    |.::|:.....|  |.|.....|       :|:|..|  |:
Human   379 ------------------------QWVAEILPSSIR--VQGRTFSQQ-------LEHLLTP--PE 408

  Fly   207 R--PCSALS-------------------------------------ERQEIKLVEEEIAAVLSG- 231
            |  .|.||.                                     |.||  |.:|:||..|.. 
Human   409 RYGVCRALESFFQHRNIDTLIVDVYPVLDTPAKQVLWQFIYQLLTYEEQE--LCQEKIACFLGYT 471

  Fly   232 ------------ESEVLKEHNVLGVNFYRIFPKPGVCMSSDVLRSLN------------EEVTKT 272
                        |||...|..          |:..:..||...|||.            .|..:.
Human   472 AMTAEPEPELDLESEPTPEPQ----------PRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEM 526

  Fly   273 KLEKDKENRQWSTFLQRPNRPVPKSKQSL--EAERRAANAYKVTIVKSAPREKSPMPEAKPAPKE 335
            .|......||.......|..|.||...::  |.|.|..:::|   .|.....||......|:|..
Human   527 PLPLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFK---GKMGTVSKSRASPPGPSPAV 588

  Fly   336 ATPPKEVEKKEEEPVPEEVVEPEPEPEKDEEPL-------PTDSEVPNLEQLPETELPDEQPEKS 393
            .|.|:.:....   .|.|.:.|.|    ...||       |:.||......|..:..|..||   
Human   589 TTGPRTLSGVS---WPSERLLPSP----CYHPLCSGGLASPSSSESHPYASLDSSRAPSPQP--- 643

  Fly   394 DAPKEVCEPEVVIQTEPGSPDGNEASDGPAGATPPAEPITPVPVKSEEELALERQLADVQRQLAA 458
             .|..:| |:     .|.|||...         ||:                       :|:|..
Human   644 -GPGPIC-PD-----SPPSPDPTR---------PPS-----------------------RRKLFT 669

  Fly   459 LSSLPSTIQST---LDAVTKQLADLLPTIKLQQQEKQLPQID--ENSGNEEQ---VEEGVTTATN 515
            .|. |...:.|   ||.:::||...:..:    .:...|:.|  |.|.:::|   |....::|::
Human   670 FSH-PVRSRDTDRFLDVLSEQLGPRVTIV----DDFLTPENDYEEMSFHDDQGSFVTNERSSASD 729

  Fly   516 TINTAGETEDAGKDISISG-SDN------------------------------------------ 537
            .|:::.|    |..::.|. ||:                                          
Human   730 CISSSEE----GSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQ 790

  Fly   538 -------------PPVGPCES-------NEDRCDANDREV----------------AEISRSTDD 566
                         ||..||..       ...|.:.:...|                .::...:|.
Human   791 LSHPVPPPPPPPLPPPVPCAPPMLSRGLGHRRSETSHMSVKRLRWEQVENSEGTIWGQLGEDSDY 855

  Fly   567 NRLAKDKKKDLDQEQKQQQQQQQEPLSEEQNFKKQKRHDVIEELEE-----------HL------ 614
            ::|: |..|.||.|.....|:..:|:...:.|:|:   :|:|.|..           ||      
Human   856 DKLS-DMVKYLDLELHFGTQKPAKPVPGPEPFRKK---EVVEILSHKKAYNTSILLAHLKLSPAE 916

  Fly   615 ----VRKNNPRRSKRA-------FGPLVPSSERPLVL---PGGRRWYRPKDAYNDEFIAETLSAQ 665
                :....|||.:.|       |.|.....:|....   ||  |...|     |:|:.:.||. 
Human   917 LRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPG--RLSEP-----DQFVLQMLSV- 973

  Fly   666 AELITGSTLGVNFMKYQKPERKIDLNRSEVYKYLNPHLDRAPVRGIEVRAPLVAAESDIRQSLQ 729
                              ||.|..|                  |.:..:|.|.....:||.||:
Human   974 ------------------PEYKTRL------------------RSLHFQATLQEKTEEIRGSLE 1001

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Zasp67NP_648358.2 PDZ_signaling 2..75 CDD:238492 19/62 (31%)
DUF4749 653..>699 CDD:292558 8/45 (18%)
GRID2IPNP_001138590.1 PDZ_signaling 14..74 CDD:238492
HN_L-delphilin-R1_like 133..212 CDD:259820
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..269
PDZ_signaling 278..353 CDD:238492 22/78 (28%)
HN_L-delphilin-R2_like 389..468 CDD:259821 19/91 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 478..502 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..549 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 568..600 8/37 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..672 18/95 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 718..783 8/68 (12%)
FH2 820..1188 CDD:280362 44/230 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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