DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and Fife

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001261340.1	Gene:	Fife / 38337	FlyBaseID:	FBgn0264606	Length:	1314	Species:	Drosophila melanogaster

Alignment Length:	680	Identity:	127/680 - (18%)
Similarity:	215/680 - (31%)	Gaps:	212/680 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WGFRLVG---GADYDYPLTVVKVTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSGS 76
            :|.|:||   |||......:|....|..|::.||:..|.|:..|..:....:.:|...::..:|.
  Fly   509 FGMRVVGGKTGADGRLFAYIVWTVPGGAAEKNGLQQGDKILEWNGMSLIDRSFEEVCSIMDRTGD 573

  Fly    77 VFYFGVYRENEEDAYEC-------------LKKFPTSEG------SLTKSPMPTISPSP-TPSLS 121
            |....|  |:..|...|             .:..|...|      .|...|..|...|| :|:..
  Fly   574 VVELLV--EHATDFRMCDLFDENLPPGNAGGQSGPRRSGDGPVGLGLIAEPETTTDKSPASPTRR 636

  Fly   122 QLTETTNARTPEPEPFVPLPRELAAATMAAPAVEVDVDVLAECRQPMSEVHSEE---KRGDVNGH 183
            :|.:|              |.::|...:....|::.|...||..:.:..:.:.:   .|.:..||
  Fly   637 KLPKT--------------PEQIAREKLVTGRVQIQVWYHAERSELVVSLMAGDDLAPRDEAYGH 687

  Fly   184 -----------------DAPGQADEGGLPVEN-----------------------LYLPDLPDRP 208
                             |...|..|...|.:|                       :.|.||....
  Fly   688 GNLPEAYAKVRILPKCGDGSVQQTEVSRPTQNPIWNATLTFGHVKADTLMVRYIDIQLWDLVPHT 752

  Fly   209 CSALSERQEIKLVEEEIAAVLSGESEVLKEHNVLGVNFYRIFPKPGV-----------CMSSDVL 262
            .|.......|:|.:    |.|..::...:..:..|:....|...|.|           ..|.||.
  Fly   753 ESIFLGECSIELQQ----AFLDDQAIWCRLEDTKGLRGISISKSPSVSPRGSIAAGAGAPSGDVT 813

  Fly   263 RSLNEEVTKTKLEKDK-ENRQWSTFLQRPNRP-VPKSKQ-SLEAERRAANAYKV--TIVKSAP-R 321
            |.|..:....:...|. ::....|.|..|:.. :..|:: |.::|......|::  ...:|.| .
  Fly   814 RLLRRDYNMQRSNSDDVDSIGDGTSLLHPDHAWIAGSRRGSSQSETMEVEVYQLGKDFSRSLPGS 878

  Fly   322 EKSPMPEAKPAPKE----ATPP---------KEVEKKEEEPVPEEVVE----------------- 356
            .:|...:|:....|    ||||         ..|.:::    |:|:::
  Fly   879 RRSSFQDAEKNRLEEDAMATPPTSYLVGRRRSSVARRD----PDEILKSLKAVRGELGRTMSLGT 939

  Fly   357 ----------------PE-PEPEKDEEPLPTDSEVPNLEQLPETELPDEQPEKSDAPKEVCEPEV 404
                            |. |...|......:......|:||.:.:|..:|..:...|..|...:
  Fly   940 EQHKRMGSRRASRVGLPSGPSSRKSSVLDLSQQHQQQLQQLQQLQLQQQQYLQQQLPMGVGNAD- 1003

  Fly   405 VIQTEPGSPDGNEAS----DGPAGATPPAEPITPVPVKSEEELALERQLADVQRQLAALSSLPST 465
               |.|.|.|.::..    .|.....||..|          :.||.|     .:|.|:.|::...
  Fly  1004 ---TSPPSEDEDKRYRPRWKGSVSQLPPQSP----------KQALSR-----LKQAASASNVAQD 1050

  Fly   466 IQSTLDAVTKQLADLLPTIKLQQQEKQLPQIDENSGNEEQVEEGVTTATN-----TINTAGETED 525
                    |::...||.|..|||::..:.|:     .|.|.....||.|:     ::..|..||.
  Fly  1051 --------TQRQGQLLTTNPLQQRKSSMFQL-----GESQASPPTTTTTHLQRKGSMYVAKVTET 1102

  Fly   526 -----------------AGKDISISGSDNP 538
                             .|..:...|:|:|
  Fly  1103 PPHGTPTRKGSVYQRSVVGLSVDSPGADSP 1132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	16/62 (26%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
Fife	NP_001261340.1	FYVE_BSN_PCLO	130..187	CDD:277290
		PDZ_signaling	491..580	CDD:238492	19/72 (26%)
		DegQ	<526..577	CDD:223343	11/50 (22%)
		C2A_RIM1alpha	651..779	CDD:175997	20/131 (15%)
		C2	1163..1304	CDD:301316
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900